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Related Concept Videos

Endocytosis01:16

Endocytosis

10.7K
Eukaryotic cells acquire nutrients for growth and proliferation. Nutrients and other molecules that require degradation are internalized from the extracellular space by a process called endocytosis. The term ‘endocytosis' was first coined by Christian de Duve in 1963.
Endocytosis always begins with the plasma membrane enclosing an incoming molecule to form a transport vesicle which, in some cases, can be coated with a protein called ‘clathrin.' Endocytosed material is either...
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Vesicular Trasport: Endocytosis, Transcytosis and Exocytosis01:18

Vesicular Trasport: Endocytosis, Transcytosis and Exocytosis

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Vesicular transport is a cellular process that encompasses the engulfment of particles or dissolved substances by cells. It involves endocytosis, transcytosis, and exocytosis.
Endocytosis is a cellular mechanism that involves the inward folding of the cell membrane to create vesicles that capture and transport large drug molecules. This process comprises two distinct methods: pinocytosis (often referred to as "cell drinking") and phagocytosis (often referred to as "cell...
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Receptor-mediated Endocytosis01:20

Receptor-mediated Endocytosis

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Receptor-mediated endocytosis is when bulk amounts of specific molecules are imported into a cell after binding to cell surface receptors. The molecules bound to these receptors are taken into the cell through inward folding of the cell surface membrane, which is eventually pinched off into a vesicle within the cell. Structural proteins, such as clathrin, coat the budding vesicle.
Clathrin-Mediated Endocytosis of LDL
One well-characterized example of receptor-mediated endocytosis is the...
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Receptor-mediated Endocytosis01:38

Receptor-mediated Endocytosis

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Overview
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Receptor-Mediated Endocytosis01:20

Receptor-Mediated Endocytosis

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Introduction to Membrane Traffic01:44

Introduction to Membrane Traffic

8.0K
The ER, Golgi apparatus, endosomes, and lysosomes work in tandem to modify, sort, and package proteins and lipids. An integrated membrane trafficking network facilitates the back and forth shuttling of molecules within different organelles in the same cell or across the cell membrane.
The transport of soluble and membrane proteins is mediated by transport vesicles that collect cargo from one cellular compartment and deliver it to another by fusing with the target organelle membrane. The Rab...
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Related Experiment Video

Updated: May 6, 2026

Analyzing Cellular Internalization of Nanoparticles and Bacteria by Multi-spectral Imaging Flow Cytometry
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Analyzing Cellular Internalization of Nanoparticles and Bacteria by Multi-spectral Imaging Flow Cytometry

Published on: June 8, 2012

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Exploiting endocytosis for nanomedicines.

Akin Akinc1, Giuseppe Battaglia

  • 1Alnylam Pharmaceuticals, Cambridge, Massachusetts 02142.

Cold Spring Harbor Perspectives in Biology
|November 5, 2013
PubMed
Summary

Cellular endocytosis pathways influence nanoparticle uptake. Understanding how nanomaterial properties affect nanomedicine endocytosis is key to developing improved therapeutics and overcoming future challenges.

Area of Science:

  • Cell Biology
  • Nanotechnology
  • Pharmacology

Background:

  • Cells utilize various endocytic pathways for internalization.
  • Physical constraints can influence nanoparticle uptake via specific pathways.
  • Nanomedicine development requires understanding cellular interactions.

Purpose of the Study:

  • To review cellular endocytic pathways and their relevance to nanoparticle internalization.
  • To explore the impact of nanomaterial parameters on nanomedicine endocytosis.
  • To highlight current nanomedicines and future research challenges.

Main Methods:

  • Literature review of endocytic pathways.
  • Analysis of how nanomaterial properties influence endocytosis.
  • Exemplification with existing nanomedicines.

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Main Results:

  • Nanoparticle uptake is directed by cellular endocytic pathways and physical limitations.
  • Nanomaterial characteristics significantly impact endocytic processes.
  • Existing nanomedicines demonstrate the therapeutic potential of exploiting endocytosis.

Conclusions:

  • Understanding nanomedicine-cell interactions is crucial for designing effective therapeutics.
  • Further research is needed to address key unanswered questions in nanomedicine delivery.