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Phases of Wound Repair01:28

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Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
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Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
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Healing II: Complications01:24

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Complications during healing arise when tissue repair is altered by local or systemic factors. These changes involve abnormal collagen deposition, altered biomechanics, and reduced vascular supply, impairing restoration of normal structure and function.Loss of FunctionScar tissue differs significantly from the original tissue it replaces. In the skin, fibrosis lacks adnexal structures such as hair follicles, sebaceous glands, and sweat glands. Their absence reduces tactile sensitivity, impairs...
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Healing I: Introduction01:11

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Healing is the physiological process by which the body restores the integrity and function of damaged tissues following injury. It involves a coordinated interplay of cellular proliferation, extracellular matrix remodeling, and growth factor signaling. The extent and nature of the tissue damage determine whether healing occurs by resolution, regeneration, or replacement.ResolutionResolution represents the most complete form of healing, occurring when the injury is minimal and tissue...
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The immune system's inflammatory response destroys the invading pathogen, permitting the tissue to heal. The changes during the cellular and vascular stages allow exudate formation at the site of inflammation. The inflammatory exudate released from the wound has high protein content and a specific gravity above 1.020.
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Related Experiment Video

Updated: May 6, 2026

Treatment of Ankle Osteoarthritis with Total Ankle Replacement Through a Lateral Transfibular Approach
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Wound healing in total joint replacement.

R E Jones1, R D Russell, M H Huo

  • 1University of Texas Southwestern Medical Center, 1801 Inwood Rd, Dallas, Texas, 75390, USA.

The Bone & Joint Journal
|November 5, 2013
PubMed
Summary
This summary is machine-generated.

Assessing patient healing capacity aids in predicting complications after total joint replacement. Addressing local and systemic factors is crucial for successful wound healing and preventing infection.

Keywords:
THRTKRWound healinginfection

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Area of Science:

  • Orthopedic surgery
  • Wound healing research

Background:

  • Primary wound healing after total joint replacement is critical for patient outcomes.
  • Wound healing complications can lead to severe patient consequences.

Purpose of the Study:

  • To highlight the importance of assessing healing capacity in predicting complications.
  • To identify local and systemic factors influencing wound healing.
  • To emphasize the need for surgical technique modifications and prompt intervention.

Main Methods:

  • Review of local factors affecting wound healing (e.g., scarring, lymphoedema, perfusion).
  • Review of systemic factors affecting wound healing (e.g., diabetes, immune status, nutrition).

Main Results:

  • Multiple factors, both local and systemic, significantly impact wound healing post-joint replacement.
  • Patient healing capacity assessment is a valuable predictor of potential complications.

Conclusions:

  • Understanding and managing pre-existing local and systemic conditions is vital for optimizing wound healing.
  • Surgical technique adjustments and timely interventions are necessary to minimize complications and infection risks.