Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

402
Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
402
Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

14.1K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
14.1K
Immunological Memory01:23

Immunological Memory

12.3K
Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
12.3K
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

387
Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...
387
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

868
As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
868
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

406
Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
406

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Trehalase-trehalose axis in the human brain: A potential modulator of neuroprotection and neurodegeneration.

Neurobiology of aging·2026
Same author

Biologically Younger Individuals, as Identified by MARK-AGE Biological Age Scores, Display a Distinct Favourable Blood Chemistry Profile Regardless of Age.

Aging cell·2026
Same author

TTV Species Diversity as a Novel Biomarker of Immune Dysregulation in Aging.

Journal of medical virology·2025
Same author

Cytomegalovirus (CMV), oxidative stress, and inflammation: implications for immunosenescence and age-related diseases in the MARK-AGE population.

Biogerontology·2025
Same author

Corrigendum to "Association of cytomegalovirus serostatus with ELOVL2 methylation: Implications for lipid metabolism, inflammation, DNA damage, and repair capacity in the MARK-AGE study population" [Mech. Ageing Dev. 225 (2025) 112043].

Mechanisms of ageing and development·2025
Same author

Association of cytomegalovirus serostatus with ELOVL2 methylation: Implications for lipid metabolism, inflammation, DNA damage, and repair capacity in the MARK-AGE study population.

Mechanisms of ageing and development·2025
Same journal

Update on Current Care Guideline: Psoriasis (skin and joints).

Duodecim; laaketieteellinen aikakauskirja·2017
Same journal

FOUR score in monitoring the level of consciousness of an intensive care patient: first experience of the use of the Finnish language version.

Duodecim; laaketieteellinen aikakauskirja·2017
Same journal

Discussing a serious illness with a patient and family.

Duodecim; laaketieteellinen aikakauskirja·2017
Same journal

Invasive treatment of superficial veins of the lower extremities.

Duodecim; laaketieteellinen aikakauskirja·2017
Same journal

When should a drain be left in the abdominal cavity upon surgery?

Duodecim; laaketieteellinen aikakauskirja·2017
Same journal

Diagnostics and current care of myasthenia gravis.

Duodecim; laaketieteellinen aikakauskirja·2017
See all related articles

Related Experiment Video

Updated: May 6, 2026

Quantitative Imaging of Lineage-specific Toll-like Receptor-mediated Signaling in Monocytes and Dendritic Cells from Small Samples of Human Blood
07:58

Quantitative Imaging of Lineage-specific Toll-like Receptor-mediated Signaling in Monocytes and Dendritic Cells from Small Samples of Human Blood

Published on: April 16, 2012

34.4K

[Immunity in the elderly].

Mikko Hurme1

  • 1Tampereen yliopisto.

Duodecim; Laaketieteellinen Aikakauskirja
|November 6, 2013
PubMed
Summary
This summary is machine-generated.

Elderly infections increase due to declining immunity, particularly T cell dysfunction and chronic inflammation ("inflamm-aging"). Cytomegalovirus infection may worsen these age-related immune changes.

More Related Videos

Isolation and Characterization of the Immune Cells from Micro-dissected Mouse Choroid Plexuses
09:55

Isolation and Characterization of the Immune Cells from Micro-dissected Mouse Choroid Plexuses

Published on: February 3, 2022

6.7K
Application of Long-term cultured Interferon-γ Enzyme-linked Immunospot Assay for Assessing Effector and Memory T Cell Responses in Cattle
15:57

Application of Long-term cultured Interferon-γ Enzyme-linked Immunospot Assay for Assessing Effector and Memory T Cell Responses in Cattle

Published on: July 11, 2015

13.8K

Related Experiment Videos

Last Updated: May 6, 2026

Quantitative Imaging of Lineage-specific Toll-like Receptor-mediated Signaling in Monocytes and Dendritic Cells from Small Samples of Human Blood
07:58

Quantitative Imaging of Lineage-specific Toll-like Receptor-mediated Signaling in Monocytes and Dendritic Cells from Small Samples of Human Blood

Published on: April 16, 2012

34.4K
Isolation and Characterization of the Immune Cells from Micro-dissected Mouse Choroid Plexuses
09:55

Isolation and Characterization of the Immune Cells from Micro-dissected Mouse Choroid Plexuses

Published on: February 3, 2022

6.7K
Application of Long-term cultured Interferon-γ Enzyme-linked Immunospot Assay for Assessing Effector and Memory T Cell Responses in Cattle
15:57

Application of Long-term cultured Interferon-γ Enzyme-linked Immunospot Assay for Assessing Effector and Memory T Cell Responses in Cattle

Published on: July 11, 2015

13.8K

Area of Science:

  • Immunology
  • Gerontology
  • Infectious Diseases

Background:

  • Aging leads to weakened immune defenses, increasing infection risks in the elderly.
  • Adaptive immunity, especially T cell function, is more affected than innate immunity.
  • Chronic, low-grade inflammation, termed "inflamm-aging," is prevalent in older adults.

Purpose of the Study:

  • To investigate the impact of aging on immune system components, focusing on T cell alterations.
  • To explore the potential association between cytomegalovirus (CMV) infection and T cell dysfunction in the elderly.
  • To understand the role of "inflamm-aging" in age-related immune decline.

Main Methods:

  • Analysis of age-associated changes in innate and adaptive immunity.
  • Assessment of T lymphocyte function, including antigen reactivity and subgroup proportions.
  • Investigation of the correlation between CMV infection and observed T cell alterations.
  • Evaluation of basal inflammation levels in elderly populations.

Main Results:

  • Significant decline in T lymphocyte function and altered functional subgroup proportions were observed with aging.
  • Cytomegalovirus infection showed a surprising association with these T cell changes.
  • Elevated basal inflammation ("inflamm-aging") was identified as a key contributing factor.

Conclusions:

  • Age-related decline in adaptive immunity, particularly T cell dysfunction, contributes to increased infection susceptibility in the elderly.
  • Cytomegalovirus infection may exacerbate age-associated T cell alterations.
  • "Inflamm-aging" is a critical factor in the compromised immune status of older adults.