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Updated: May 6, 2026

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
Published on: March 6, 2018
Chemoprevention of prostate cancer
Goutham Vemana1, Robert J Hamilton, Gerald L Andriole
1Division of Urologic Surgery, Washington University School of Medicine in St. Louis, Siteman Cancer Center, St. Louis, Missouri; email: vemanag@wudosis.wustl.edu ; andrioleg@wustl.edu.
Abstract:
Large prospective randomized trials, such as the Prostate Cancer Prevention Trial (PCPT), Reduction by Dutasteride of Prostate Cancer Events (REDUCE) trial, and Selenium and Vitamin E Cancer Prevention Trial (SELECT), have provided practitioners with considerable data regarding methods of treatment and prevention of prostate cancer. The best-studied medications for prevention are 5 alpha-reductase inhibitors. Their efficacy and side effects are well characterized. Other medications, dietary nutrients, and supplements have not been as well studied and generally do not demonstrate efficacy for disease prevention with an acceptable level of evidence.
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