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Paraparesis in a Golden Retriever.
S Aschenbroich1, A Woolcock2, D R Rissi3
1Department of Pathology, College of Veterinary Medicine, The University of Georgia, Athens, GA, USA.
Veterinary Pathology
|November 7, 2013
Summary
A Golden Retriever dog experienced fever and neurological issues. Necropsy revealed widespread nodules, leading to a diagnosis of a rare canine epitheliotropic T-cell lymphoma.
Area of Science:
- Veterinary Pathology
- Canine Oncology
Background:
- Epitheliotropic T-cell lymphoma (ETCL) is a rare cutaneous lymphoma in dogs.
- This case presents a disseminated, non-cutaneous form of ETCL with extensive organ involvement.
Observation:
- A 7-year-old Golden Retriever presented with fever, paraparesis, and ataxia.
- Radiographs showed a miliary pulmonary pattern.
- Necropsy revealed multifocal nodules in lungs, heart, mesentery, pancreas, intestines, brain, and spinal cord.
Findings:
- Cytology of pulmonary nodules showed epithelioid and spindle cells.
- Histochemistry and immunohistochemistry confirmed multifocal epitheliotropic T-cell lymphoma.
- The tumor infiltrated multiple organs, presenting as a systemic disease.
Implications:
- This case highlights the potential for disseminated, extranodal ETCL in dogs.
- Early recognition and diagnosis are crucial for managing this aggressive neoplasm.
- Further research into the pathogenesis and treatment of systemic ETCL is warranted.
