Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chronic Pancreatitis I: Introduction01:25

Chronic Pancreatitis I: Introduction

29
Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80%...
29
Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

918
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
918
Acute Pancreatitis I: Introduction01:25

Acute Pancreatitis I: Introduction

31
Acute pancreatitis is the sudden inflammation of the pancreas caused by the early activation of digestive enzymes, leading to the autodigestion of pancreatic tissue. This results in local inflammation and, in severe cases, systemic complications.EtiologyUnderstanding the underlying causes is crucial, as identifying the etiology guides treatment and anticipates complications. Acute pancreatitis can be triggered by various factors, typically grouped into the following clinical categories.Biliary...
31
Acute Pancreatitis I: Introduction01:27

Acute Pancreatitis I: Introduction

1.5K
Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
1.5K
Chronic Pancreatitis II: Pathophysiology01:21

Chronic Pancreatitis II: Pathophysiology

36
Chronic pancreatitis is a progressive and irreversible inflammation of the pancreas, most often caused by long-term alcohol abuse, but it can also be related to ductal obstruction, smoking, or genetic factors.Chronic pancreatitis occurs when the pancreas is repeatedly exposed to harmful agents like alcohol, smoking, ductal obstruction, or genetic predisposition. These factors lead to the release of toxic metabolites and inflammatory cytokines, sustaining chronic inflammation in the pancreatic...
36
Acute Pancreatitis II: Pathophysiology01:21

Acute Pancreatitis II: Pathophysiology

52
The pathophysiology of acute pancreatitis centers on injury to pancreatic acinar cells, which initiates a cascade of harmful intracellular events.This injury leads to premature activation of trypsinogen to trypsin in the pancreas. Trypsin then activates other digestive enzymes, such as chymotrypsin, elastase, and phospholipase A2, which begin breaking down pancreatic tissue. The resulting autodigestion causes local inflammation, tissue swelling, hemorrhage, and fat necrosis.Injured acinar cells...
52

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

German guidelines for the diagnosis and treatment of squamous-cell carcinoma and adenocarcinoma of the esophagus-version 4.0.

ESMO gastrointestinal oncology·2026
Same author

Changes over time in the course of advanced pancreatic cancer treatment with systemic chemotherapy: a pooled analysis of five clinical trials from two decades of the German AIO study group.

ESMO open·2024
Same author

Interobserver agreement on definition of the target volume in stereotactic radiotherapy for pancreatic adenocarcinoma using different imaging modalities.

Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]·2023
Same author

Cancer of unknown primary (CUP) through the lens of precision oncology: a single institution perspective.

Journal of cancer research and clinical oncology·2023
Same author

The impact of endoscopic activity on musculoskeletal disorders of high-volume endoscopists in Germany.

Scientific reports·2022
Same author

[Diagnostic Imaging of pancreatic carcinoma-Update of the new guideline].

Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen·2022
Same journal

Deutsche medizinische Wochenschrift (1946)·2026
Same journal

["Not everything that looks like a tumor..." - Pulmonary tularemia with hilar lymphadenopathy].

Deutsche medizinische Wochenschrift (1946)·2026
Same journal

[Emergency management of sickle cell disease].

Deutsche medizinische Wochenschrift (1946)·2026
Same journal

[Hereditary dehydrated stomatocytosis (= hereditary xerocytosis) - Interesting hummingbird or clinically relevant diagnosis?]

Deutsche medizinische Wochenschrift (1946)·2026
Same journal

[Diagnosis of Congenital Hemolytic Anemias in Adults].

Deutsche medizinische Wochenschrift (1946)·2026
Same journal

[46-year-old female patient with right upper abdominal pain].

Deutsche medizinische Wochenschrift (1946)·2026
See all related articles

Related Experiment Video

Updated: May 6, 2026

A Simple and Rapid Method for Simultaneous Isolation of Primary Islets and Primary Pancreatic Acinar Cells from Mice
14:39

A Simple and Rapid Method for Simultaneous Isolation of Primary Islets and Primary Pancreatic Acinar Cells from Mice

Published on: January 9, 2026

1.1K

[Autoimmune pancreatitis].

G Beyer1, J Menzel, P-C Krüger

  • 1Klinik für Innere Medizin A, Universitätsmedizin Greifswald, Ernst-Moritz-Arndt-Universität Greifswald.

Deutsche Medizinische Wochenschrift (1946)
|November 7, 2013
PubMed
Summary
This summary is machine-generated.

Autoimmune pancreatitis (AIP) is a rare chronic pancreatitis with two subtypes. Early diagnosis and steroid treatment are crucial, but differentiating AIP from pancreatic cancer remains challenging.

More Related Videos

Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice
06:35

Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice

Published on: June 28, 2021

3.5K
A Mouse Model for Chronic Pancreatitis via Bile Duct TNBS Infusion
06:44

A Mouse Model for Chronic Pancreatitis via Bile Duct TNBS Infusion

Published on: February 28, 2021

3.6K

Related Experiment Videos

Last Updated: May 6, 2026

A Simple and Rapid Method for Simultaneous Isolation of Primary Islets and Primary Pancreatic Acinar Cells from Mice
14:39

A Simple and Rapid Method for Simultaneous Isolation of Primary Islets and Primary Pancreatic Acinar Cells from Mice

Published on: January 9, 2026

1.1K
Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice
06:35

Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice

Published on: June 28, 2021

3.5K
A Mouse Model for Chronic Pancreatitis via Bile Duct TNBS Infusion
06:44

A Mouse Model for Chronic Pancreatitis via Bile Duct TNBS Infusion

Published on: February 28, 2021

3.6K

Area of Science:

  • Gastroenterology and Immunology
  • Pancreatology

Context:

  • Autoimmune pancreatitis (AIP) is a rare chronic inflammatory condition affecting the pancreas.
  • It presents with distinct histological features and clinical manifestations, often mimicking pancreatic cancer.

Purpose:

  • To summarize recent advances in the epidemiology, clinical presentation, diagnosis, therapy, and differential diagnosis of autoimmune pancreatitis.
  • To highlight the challenges in distinguishing AIP from pancreatic cancer.

Summary:

  • AIP is characterized by lymphoplasmacytic infiltrate and storiform fibrosis, presenting as two subtypes: Type 1 (IgG4-associated) and Type 2 (IgG4-negative).
  • Diagnosis often requires histological confirmation or response to steroids, with Type 1 associated with IgG4-syndrome and Type 2 with inflammatory bowel disease.
  • Both types typically respond to steroids, but Type 1 has a higher relapse rate. Differentiating AIP from pancreatic cancer is critical due to overlapping symptoms.

Impact:

  • Provides a comprehensive overview of autoimmune pancreatitis for clinicians and researchers.
  • Emphasizes the importance of accurate diagnosis and differential diagnosis for improved patient management.
  • Contributes to a better understanding of this rare pancreatic disease and its management strategies.