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Generation of Oligodendrocytes and Oligodendrocyte-Conditioned Medium for Co-Culture Experiments
Published on: February 9, 2020
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Oligodendrogenesis after cerebral ischemia
Ruilan Zhang1, Michael Chopp, Zheng Gang Zhang
1Department of Neurology, Henry Ford Hospital Detroit, MI, USA.
Frontiers in Cellular Neuroscience
|November 7, 2013
Summary
Stroke triggers the generation and maturation of oligodendrocyte progenitor cells (OPCs) in the brain. Therapies can enhance this natural repair process for ischemic brain injury.
Area of Science:
- Neuroscience
- Stem Cell Biology
- Cerebrovascular Research
Background:
- Neural stem cells in the subventricular zone (SVZ) generate oligodendrocyte progenitor cells (OPCs).
- OPCs migrate to the corpus callosum and striatum, differentiating into mature oligodendrocytes.
- Cerebral ischemia during stroke induces oligodendrogenesis as part of brain repair.
Purpose of the Study:
- To review evidence of stroke-induced OPC proliferation and differentiation.
- To explore therapies that enhance endogenous oligodendrogenesis in ischemic brains.
Main Methods:
- Review of existing literature on stroke models and oligodendrogenesis.
- Analysis of OPC origins (resident white matter vs. SVZ).
- Examination of therapeutic strategies targeting OPCs.
Main Results:
- Cerebral ischemia stimulates both resident and SVZ-derived OPCs to proliferate and differentiate.
- Oligodendrogenesis is a key component of the brain's endogenous repair mechanisms post-stroke.
- Therapeutic interventions show potential for amplifying this process.
Conclusions:
- Stroke activates endogenous mechanisms involving OPCs for brain repair.
- Targeting and enhancing oligodendrogenesis presents a promising therapeutic avenue for stroke recovery.
Keywords:
cerebral ischemiamicroRNAsneural stem cellsoligodendrocyte progenitor cellsoligodendrocytesMore Related Videos
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