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Prognostic impact of thyroid stimulating hormone levels in patients with cardiomyopathy

Talhat Azemi1, Sanjeev Bhavnani, Fawad Kazi

  • 1Hartford Hospital, Hartford, USA.

Connecticut Medicine
|November 8, 2013
PubMed

Insights

Thyroid stimulating hormone (TSH) abnormalities predict mortality in cardiomyopathy patients. However, TSH levels did not influence implantable cardioverter defibrillator (ICD) therapies in this population.

Area of Science:

  • Cardiology
  • Endocrinology
  • Medical Devices

Background:

  • Thyroid stimulating hormone (TSH) abnormalities are linked to cardiac arrhythmias.
  • The impact of TSH levels on mortality and implantable cardioverter defibrillator (ICD) behavior in cardiomyopathy patients remains unclear.

Purpose of the Study:

  • To investigate the association between TSH abnormalities and mortality.
  • To evaluate the effect of TSH levels on ICD therapies in patients with cardiomyopathy.

Main Methods:

  • Analysis of 371 patients with available TSH levels from an ICD database (1997-2008).
  • Patients categorized into High TSH (>5) and Low TSH (<0.4) groups.
  • Comparison of mortality and ICD therapies (appropriate and inappropriate) between TSH groups.

Main Results:

  • Both high and low TSH levels independently predicted all-cause mortality (HR 1.46 and 1.76, respectively).
  • TSH abnormalities were not associated with an increased incidence of appropriate or inappropriate ICD therapy.

Conclusions:

  • TSH levels are significant predictors of all-cause mortality in cardiomyopathy patients.
  • TSH levels do not appear to be predictors of appropriate or inappropriate ICD therapy.
Abstract

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