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Related Concept Videos

Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
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Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

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A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
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Stem Cell Culture01:17

Stem Cell Culture

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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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iPS Cell Differentiation01:22

iPS Cell Differentiation

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The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
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Tissue Renewal without Stem Cells01:23

Tissue Renewal without Stem Cells

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After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
However, failure of such a system...
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Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

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Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
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Related Experiment Video

Updated: May 6, 2026

Microdissection of Primary Renal Tissue Segments and Incorporation with Novel Scaffold-free Construct Technology
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Stem cells: potential and challenges for kidney repair.

Marcela Herrera1, Maria Mirotsou

  • 1Division of Cardiology, Genome Research Bldg. II, Rm. 4022, 210 Research Drive, Duke Univ. Medical Center, Durham, NC 27710. maria.mirotsou@duke.edu.

American Journal of Physiology. Renal Physiology
|November 8, 2013
PubMed
Summary

Kidney injury is a major health issue. Stem cells show promise for repairing damaged kidneys, offering new therapeutic potential beyond dialysis or transplantation.

Keywords:
acute kidney injurychronic kidney diseasekidney repairregenerationreprogrammingstem cells

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Area of Science:

  • Nephrology
  • Stem Cell Biology
  • Regenerative Medicine

Background:

  • Acute and chronic kidney injury represent significant public health challenges.
  • Current treatments for end-stage renal disease (ESRD) are limited to kidney transplantation or dialysis.
  • There is a critical need for novel therapies to prevent and reverse kidney damage.

Purpose of the Study:

  • To review recent findings on the role of progenitor and stem cells in kidney repair.
  • To discuss the therapeutic potential of stem cells for treating kidney diseases.

Main Methods:

  • Literature review of studies investigating stem cell involvement in renal repair.
  • Analysis of research on progenitor cell function in various kidney pathologies.

Main Results:

  • Evidence suggests the kidney possesses a capacity for self-repair.
  • Progenitor and stem cells play crucial roles in kidney regeneration under pathological conditions.

Conclusions:

  • Stem cells represent a promising therapeutic avenue for kidney diseases.
  • Further research into stem cell-based therapies could revolutionize kidney disease treatment.