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Eccrine angiomatous hamartoma is a lymphatic proliferation
Lei Wang1, Shuang Wang, Tianwen Gao
1Department of Dermatology, Xijing hospital, Fourth Military Medical University, 15 Changlexi Road, 710032 Xian, China.
European Journal of Dermatology : EJD
|November 9, 2013
Summary
Eccrine angiomatous hamartoma (EAH) shows lymphatic vessel proliferation, indicated by Prox1 and D2-40 markers. Researchers suggest renaming it eccrine lymphangiomatous hamartoma based on these findings.
Area of Science:
- Dermatopathology
- Histogenesis
- Immunohistochemistry
Background:
- Eccrine angiomatous hamartoma (EAH) is a vascular hamartoma.
- Characterized by abnormal proliferation of blood vessels and eccrine glands.
Purpose of the Study:
- Investigate immunohistochemical markers D2-40 and Prox1 in EAH.
- Gain insight into the histogenesis of EAH.
Main Methods:
- Analyzed 21 diagnosed cases of EAH.
- Performed immunohistochemical staining for D2-40 and Prox1.
Main Results:
- Prox1 was positive in all cases' endothelial cells.
- D2-40 was positive in 3 cases and focally positive in 18 cases' endothelial cells.
Conclusions:
- EAH demonstrates lymphatic proliferation.
- Suggest renaming EAH to eccrine lymphangiomatous hamartoma.
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