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Hematologic disease in scleroderma syndromes.

J A Doyle, S M Connolly, H C Hoagland

    Acta Dermato-Venereologica
    |January 1, 1985
    PubMed
    Summary
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    Scleroderma and related conditions may rarely be associated with serious hematologic diseases, including lymphoproliferative disorders. A temporal link was observed in some cases, suggesting a potential connection between these autoimmune and blood-related conditions.

    Area of Science:

    • Dermatology
    • Hematology
    • Oncology

    Background:

    • Scleroderma, morphea, and eosinophilic fasciitis are connective tissue diseases.
    • Hematologic diseases encompass a range of blood and bone marrow disorders.
    • The co-occurrence of these conditions is not well-established.

    Purpose of the Study:

    • To investigate the potential association between scleroderma spectrum diseases and serious hematologic conditions.
    • To identify the frequency and temporal relationship of hematologic disorders in patients with scleroderma, morphea, or eosinophilic fasciitis.

    Main Methods:

    • Retrospective review of 4,430 patient records.
    • Identification of patients diagnosed with scleroderma, morphea, or eosinophilic fasciitis.
    • Analysis of co-existing hematologic diagnoses and their onset relative to the connective tissue disease.

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    Main Results:

    • Sixteen out of 4,430 patients (0.36%) had a serious hematologic disease.
    • Hematologic conditions included various serious disorders.
    • Seven patients exhibited a close temporal relationship between the onset of the dermatologic and hematologic conditions.

    Conclusions:

    • Serious hematologic diseases, particularly lymphoproliferative processes, can rarely occur in patients with systemic or localized scleroderma, morphea, and eosinophilic fasciitis.
    • A temporal association suggests a possible link that warrants further investigation.
    • Clinicians should be aware of this potential comorbidity.