Related Experiment Video

Updated: Jul 15, 2026

Retroviral Transduction of T-cell Receptors in Mouse T-cells
10:14

Retroviral Transduction of T-cell Receptors in Mouse T-cells

Published on: October 22, 2010

The trans-activator gene of the human T cell lymphotropic virus type III is required for replication

A I Dayton, J G Sodroski, C A Rosen

    Cell
    |March 28, 1986
    PubMed

    More Related Videos

    Adenoviral Transduction of Naive CD4 T Cells to Study Treg Differentiation15:33

    Adenoviral Transduction of Naive CD4 T Cells to Study Treg Differentiation

    Published on: August 13, 2013

    Generating De Novo Antigen-specific Human T Cell Receptors by Retroviral Transduction of Centric Hemichain08:48

    Generating De Novo Antigen-specific Human T Cell Receptors by Retroviral Transduction of Centric Hemichain

    Published on: October 25, 2016

    Related Concept Videos

    LTR Retrotransposons03:08

    LTR Retrotransposons

    LTR retrotransposons are class I transposable elements with long terminal repeats flanking an internal coding region. These elements are less abundant in mammals compared to other class I transposable elements. About 8 percent of human genomic DNA comprises LTR retrotransposons. Some of the common examples of LTR retrotransposons are Ty elements in yeast and Copia elements in Drosophila.
    The internal coding region of LTR retrotransposons and their mechanism of transposition closely resembles a...
    RNA Polymerase II Accessory Proteins02:36

    RNA Polymerase II Accessory Proteins

    Proteins that regulate transcription can do so either via direct contact with RNA Polymerase or through indirect interactions facilitated by adaptors, mediators, histone-modifying proteins, and nucleosome remodelers. Direct interactions to activate transcription is seen in bacteria as well as in some eukaryotic genes. In these cases, upstream activation sequences are adjacent to the promoters, and the activator proteins interact directly with the transcriptional machinery. For example, in...
    Eukaryotic Transcription Activators02:42

    Eukaryotic Transcription Activators

    Transcription activators are proteins that promote the transcription of genes from DNA to RNA. In most cases, these proteins contain two separate domains ‒ a domain that binds to DNA and a domain for activating transcription; however, in some cases, a single domain is responsible for both binding and activation of transcription, as seen in the glucocorticoid receptor and MyoD.
    The binding domains are capable of recognizing and interacting with regulatory sequences on the DNA. These domains are...
    General Transcription Factors01:30

    General Transcription Factors

    Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
    T Cell Activation and Clonal Selection01:22

    T Cell Activation and Clonal Selection

    T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
    Naive T cells that have not yet encountered an antigen express two primary CD...
    Size and Structure of Viral Genomes01:26

    Size and Structure of Viral Genomes

    Viral genomes exhibit remarkable diversity in size, structure, and composition, influencing their replication strategies and interactions with host cells. These genomes consist of either DNA or RNA and may be linear or circular. Additionally, they can be single-stranded or double-stranded, with each configuration affecting how the virus propagates within a host. RNA viruses, for instance, generally have smaller genomes than DNA viruses, a factor that contributes to their high mutation rates and...