Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Antigen handling by the small intestine.

W A Walker

    Clinics in Gastroenterology
    |January 1, 1986
    PubMed
    Summary

    The mature gut absorbs antigens via pinocytosis, a process usually harmless due to the mucosal barrier. Disruption of this barrier can lead to diseases from absorbed macromolecules.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Helminth-induced alterations of the gut microbiota exacerbate bacterial colitis.

    Mucosal immunology·2017
    Same author

    Antigen uptake in the gut: immunologic implications.

    Immunology today·2014
    Same author

    The role of gut microbiota in programming the immune phenotype.

    Journal of developmental origins of health and disease·2013
    Same author

    Vaginal calculi in the dolphin.

    Journal of wildlife diseases·2013
    Same author

    Immune factors in breast milk and the development of atopic disease.

    Journal of pediatric gastroenterology and nutrition·2012
    Same author

    Cerebral complications of frontal sinusitis.

    Staff proceedings. Hillcrest Medical Center (Tulsa, Okla.)·2010

    Area of Science:

    • Gastroenterology
    • Immunology
    • Cell Biology

    Background:

    • The intestine's role in handling luminal antigens is poorly understood.
    • Mature gut retains antigen absorption capacity via energy-dependent pinocytosis.
    • This process is similar to neonatal gamma-globulin transport in mammals.

    Purpose of the Study:

    • To review current research on intestinal antigen handling.
    • To elucidate the mechanisms and implications of luminal antigen absorption.
    • To discuss the link between mucosal barrier function and disease.

    Main Methods:

    • Literature review of gastroenterology and immunology research.
    • Analysis of cellular mechanisms of antigen transport (pinocytosis).
    • Discussion of the intestinal mucosal barrier's role.

    Main Results:

    • Adults possess a physiological antigen absorption mechanism.
    • The mucosal barrier normally prevents adverse effects from this absorption.
    • Disrupted barriers allow pathological macromolecule entry, altering antigen handling.
    • Altered antigen handling can cause local intestinal or systemic diseases.

    Conclusions:

    • Intestinal antigen handling is a complex physiological process.
    • Mucosal barrier integrity is crucial for preventing disease.
    • Altered mucosal permeability is a potential factor in various clinical conditions.

    Related Experiment Videos