Related Experiment Video

Updated: May 6, 2026

Author Spotlight: Collecting the Brain and Serum from the Same Mice Fetus to Study Brain Tumor Development
05:44

Author Spotlight: Collecting the Brain and Serum from the Same Mice Fetus to Study Brain Tumor Development

Published on: May 17, 2024

1.3K

Maternal prepregnancy body mass index and gestational weight gain on offspring overweight in early infancy

Nan Li1, Enqing Liu, Jia Guo

  • 1Tianjin Women's and Children's Health Center, Tianjin, China ; Chronic Disease Epidemiology Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana, United States of America.

Plos One
|November 9, 2013
PubMed

Insights

Maternal prepregnancy overweight/obesity and excessive gestational weight gain (GWG) are linked to greater infant growth. Excessive GWG increases the risk of childhood overweight and obesity.

Area of Science:

  • Pediatrics
  • Obstetrics
  • Public Health

Background:

  • Maternal prepregnancy body mass index (BMI) and gestational weight gain (GWG) are critical factors influencing offspring's early growth and development.
  • Understanding these associations is vital for developing targeted interventions to promote healthy child development.

Purpose of the Study:

  • To evaluate the association between maternal prepregnancy BMI and GWG with offspring anthropometry from birth to 12 months in Tianjin, China.

Main Methods:

  • A cohort of 38,539 pregnant women and their children were studied between 2009 and 2011.
  • Offspring anthropometry was measured at birth and at 3, 6, 9, and 12 months.
  • General Linear Models and Logistic Regression were used to analyze the associations.

Main Results:

  • Maternal prepregnancy BMI and GWG positively correlated with offspring's birth weight and length Z-scores.
  • Excessive GWG led to significant changes in weight-for-age and length-for-age Z-scores in infants.
  • Excessive GWG was associated with a higher risk of offspring overweight or obesity at 12 months.

Conclusions:

  • Maternal overweight/obesity and excessive GWG are linked to accelerated infant weight and length gain.
  • Excessive GWG significantly elevates the risk of infant overweight and obesity.
Abstract

More Related Videos

Instrumentation of Near-term Fetal Sheep for Multivariate Chronic Non-anesthetized Recordings14:40

Instrumentation of Near-term Fetal Sheep for Multivariate Chronic Non-anesthetized Recordings

Published on: October 25, 2015

8.3K
Author Spotlight: Exploring the Long-Term Health Impacts of Intracytoplasmic Sperm Injection on Offspring06:11

Author Spotlight: Exploring the Long-Term Health Impacts of Intracytoplasmic Sperm Injection on Offspring

Published on: May 17, 2024

1.3K

Related Concept Videos

Obesity01:24

Obesity

The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
1.6K
Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
3.9K
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
5.0K
Drug Dosing: Obese Patients01:21

Drug Dosing: Obese Patients

In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...
372
Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
30.4K
Bulimia Nervosa01:30

Bulimia Nervosa

Bulimia nervosa is a complex and severe eating disorder characterized by a cyclical pattern of binge-and-purge eating pattern. It generally involves an episode of binge eating, followed by compensatory behaviors such as vomiting, excessive exercise, laxative use, or fasting, to prevent weight gain. Despite often maintaining a normal weight, individuals with bulimia are intensely preoccupied with their body image and harbor an overwhelming fear of gaining weight. This can contribute to the...
1.1K