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Updated: May 6, 2026
07:24
Intravitreal Injection and Quantitation of Infection Parameters in a Mouse Model of Bacterial Endophthalmitis
Published on: February 6, 2021
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Scedosporium prolificans endogenous endophthalmitis
Nathalie Chiam1, Loreto V T Rose, Keith D Waters
1Department of Ophthalmology, Royal Children's Hospital, Parkville, Victoria, Australia.
Summary
Scedosporium prolificans can cause serious infections in immunocompromised individuals. This case highlights successful treatment of endogenous S. prolificans endophthalmitis in a child with acute myeloid leukemia.
Area of Science:
- Mycology
- Ophthalmology
- Hematology-Oncology
Background:
- Scedosporium prolificans is an opportunistic fungal pathogen.
- It commonly affects immunocompromised patients, leading to sepsis and endophthalmitis.
- Endogenous endophthalmitis is a rare but severe intraocular infection.
Observation:
- A 9-year-old girl with acute myeloid leukemia (AML) developed endogenous S. prolificans endophthalmitis.
- The infection occurred following chemotherapy treatment for AML.
- The patient presented with symptoms indicative of intraocular inflammation.
Findings:
- Diagnosis was confirmed by identifying S. prolificans in ocular samples.
- The patient received intensive antifungal therapy tailored to the identified pathogen.
- Prompt and appropriate treatment led to a favorable clinical response.
Implications:
- This case underscores the importance of considering rare fungal infections in febrile neutropenic patients.
- Early diagnosis and aggressive antifungal treatment are crucial for visual salvage in S. prolificans endophthalmitis.
- Management requires a multidisciplinary approach involving infectious diseases, ophthalmology, and hematology.
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