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Decreased Body Temperature01:29

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A decreased body temperature can occur in patients with hypothermia and frostbite. Heat loss with extended cold exposure overpowers the body's ability to create heat, resulting in hypothermia. Core temperature readings help classify hypothermia. Mild hypothermia is temperatures between 32 °C (89.6 °F) and 35°C (95 °F) and is caused by impaired thermoregulation. Moderate hypothermia is temperatures between 28 C (82.4 °F) and 32 °C (89.6 °F) caused by...
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Every organism has an optimum temperature range within which healthy growth and physiological functioning can occur. At the ends of this range, there will be a minimum and maximum temperature that interrupt biological processes.
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Supportive cryotherapy: a review from head to toe.

Kunal C Kadakia1, Shaina A Rozell1, Anish A Butala2

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Regional hypothermia effectively reduces chemotherapy side effects like oral mucositis and hair loss. This cryotherapy approach is well-tolerated, offering a promising intervention for cancer patients experiencing these adverse events.

Keywords:
Cryotherapyalopeciamucositisonycholysisregional hypothermia

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Area of Science:

  • Oncology
  • Pharmacology
  • Dermatology

Background:

  • Conventional chemotherapy causes severe mucocutaneous complications, including oral mucositis, alopecia, ocular toxicity, and onycholysis.
  • Current pharmacologic interventions for preventing these side effects are limited.

Purpose of the Study:

  • To critically review the efficacy of cryotherapy (regional hypothermia) in alleviating chemotherapy-induced adverse mucocutaneous symptoms.

Main Methods:

  • A narrative review focused on randomized controlled trials.
  • Comprehensive literature search across major databases (PubMed, Ovid, Embase, MEDLINE).
  • Included studies published between 1970 and May 2013, with reference list review.

Main Results:

  • Evidence indicates regional hypothermia reduces the incidence and severity of chemotherapy-related oral mucositis, alopecia, ocular toxicity, and onycholysis.
  • Identified limitations include a lack of blinded control groups and inconsistent clinical endpoints in existing studies.

Conclusions:

  • Regional hypothermia is a well-tolerated method for decreasing four major chemotherapy-induced complications.
  • Further research is required to optimize patient selection, cooling duration, and device usability.