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Related Experiment Video

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Single-stage Dynamic Reanimation of the Smile in Irreversible Facial Paralysis by Free Functional Muscle Transfer
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A new facial expression to botox!

Aakash Aggarwal1, Viren Kaul1, Gurmeen Kaur1

  • 1SUNY Upstate Medical University, Syracuse, NY 13202, USA.

The American Journal of Emergency Medicine
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Botulinum toxin (Botox) injections for achalasia cardia can cause rare but severe anaphylaxis. This case highlights an under-reported adverse effect of Botox, emphasizing the need for clinical awareness.

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Area of Science:

  • Gastroenterology
  • Clinical Immunology

Background:

  • Botulinum toxin (Botox) injections into the lower esophageal sphincter (LES) are an established treatment for achalasia cardia.
  • It is typically reserved for patients unsuitable for or with recurrent symptoms after definitive therapies like Heller's myotomy or pneumatic dilation.

Observation:

  • A rare case of severe anaphylaxis following Botox injection for achalasia cardia is presented.
  • This adverse event occurred despite the established safety profile of Botox in gastrointestinal procedures.

Findings:

  • Anaphylactic reactions to Botox are exceedingly rare, with only one prior reported case.
  • The clinical significance of this severe adverse effect has been under-emphasized in medical literature and practice.

Implications:

  • Clinicians should be aware of the potential for severe anaphylaxis as an adverse effect of Botox injections.
  • Further research and reporting are needed to fully understand the incidence and management of anaphylaxis related to therapeutic Botox use.