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Updated: May 6, 2026
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Identification of Novel CK2 Kinase Substrates Using a Versatile Biochemical Approach
Published on: February 21, 2019
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Protein kinase a in cancer
Antonio Caretta1, Carla Mucignat-Caretta
1Department of Human Anatomy and Physiology, University of Padova, Via Marzolo 3, 35131 Padova, Italy. carla.mucignat@unipd.it.
Cancers
|November 12, 2013
Summary
Epigenetic changes in the cyclic adenosine monophosphate (cAMP) system, particularly protein kinase A (PKA), may drive tumor development. PKA could serve as a biomarker for cancer detection and a therapeutic target.
Area of Science:
- Oncology
- Molecular Biology
- Cellular Signaling
Background:
- Cancer often lacks clear genetic signatures, suggesting other cellular processes are involved.
- Epigenetic modifications, especially in second messenger systems, can alter cell function and lead to carcinogenesis.
- The cyclic adenosine monophosphate (cAMP) system is crucial for regulating cellular functions.
Purpose of the Study:
- To investigate the role of the cAMP system and its downstream effectors in tumor initiation and growth.
- To explore the functional significance of modifications in second messenger pathways.
- To assess the potential of cAMP-activated protein kinase (PKA) as a cancer biomarker and therapeutic target.
Main Methods:
- Analysis of chromosomal and genetic alterations in tumors.
- Examination of epigenetic modulation of second messenger systems.
- Investigation of intracellular compartmentalization and gene expression changes.
- Focus on the cAMP signaling pathway and its interaction with protein kinase A (PKA).
Main Results:
- Some tumors lack distinct molecular or genetic profiles, indicating involvement of other cellular mechanisms.
- Epigenetic modulation of second messenger systems, like cAMP, can impact cellular processes, including mitosis.
- Protein kinase A (PKA), activated by cAMP, is implicated in the onset and progression of various tumors.
Conclusions:
- The cAMP-PKA pathway is a significant factor in cancer development and progression.
- PKA holds potential as a biomarker for tumor detection, staging, and as a target for cancer pharmacotherapy.
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