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Related Experiment Video

Updated: May 6, 2026

Author Spotlight: Advancing Research on Candida albicans Biofilm-Associated Prosthetic Joint Infections

Author Spotlight: Advancing Research on Candida albicans Biofilm-Associated Prosthetic Joint Infections

Published on: February 2, 2024

Review: Microbial colonization of prosthetic devices.

M Jacques¹, T J Marrie, J W Costerton

¹Department of Biology, University of Calgary, Calgary, Alberta, Canada.

Microbial Ecology

|November 12, 2013

Summary

Bacterial colonization and biofilm formation are major challenges for prosthetic devices. Understanding these microbial communities is crucial for preventing and treating infections associated with biomaterials.

Area of Science:

Biomaterials Science
Microbiology
Infectious Diseases

Background:

Prosthetic devices are essential in modern medicine.
Bacterial colonization and biofilm formation present significant challenges.
These microbial communities can lead to serious infections.

Purpose of the Study:

To highlight the limitations imposed by bacterial colonization on prosthetic devices.
To emphasize the role of biofilms in biomaterial-associated infections.
To underscore the need for better prevention and treatment strategies.

Main Methods:

Literature review and data synthesis.
Analysis of microbial adherence mechanisms.
Evaluation of biofilm resistance to host defenses and antibiotics.

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A Zebrafish Embryo Model for In Vivo Visualization and Intravital Analysis of Biomaterial-associated Staphylococcus aureus Infection

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Last Updated: May 6, 2026

Author Spotlight: Advancing Research on Candida albicans Biofilm-Associated Prosthetic Joint Infections

Author Spotlight: Advancing Research on Candida albicans Biofilm-Associated Prosthetic Joint Infections

Published on: February 2, 2024

Animal Model of Implant-Associated Infections in Mice

Animal Model of Implant-Associated Infections in Mice

Published on: June 27, 2025

A Zebrafish Embryo Model for In Vivo Visualization and Intravital Analysis of Biomaterial-associated Staphylococcus aureus Infection

A Zebrafish Embryo Model for In Vivo Visualization and Intravital Analysis of Biomaterial-associated Staphylococcus aureus Infection

Published on: January 7, 2019

Main Results:

Bacterial colonization and biofilm formation are key limitations for prosthetic devices.
Microbial adherence via the glycocalyx is central to biomaterial sepsis.
Biofilms confer resistance to host defenses and antibiotic therapies.

Conclusions:

A comprehensive understanding of biofilm formation is necessary.
Effective strategies are needed to prevent and eliminate protected microbial reservoirs.
Addressing biofilm challenges will advance the use of medical prosthetics.