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Genetic variants associated with exercise performance in both moderately trained and highly trained individuals
N R Harvey1,2, S Voisin3, P J Dunn2
1Health Sciences and Medicine Faculty, Bond University, Robina, QLD, 4226, Australia.
Molecular Genetics and Genomics : MGG
|January 4, 2020
Summary
Genetic variants influence exercise training adaptation. A study found 17 genetic variants associated with endurance performance gains, with IL6 rs1474347 linked to improved maximal oxygen uptake after training.
Area of Science:
- Exercise physiology
- Human genetics
- Sports science
Background:
- Exercise training adaptation is a complex trait influenced by genetic factors.
- Previous research identified single nucleotide polymorphisms (SNPs) associated with exercise performance and intolerance.
Purpose of the Study:
- To investigate the association between 36 pre-identified single nucleotide polymorphisms (SNPs) and endurance fitness phenotypes.
- To explore the role of genetic variants in individual responses to exercise training.
Main Methods:
- Genotyping of 36 SNPs using a MassARRAY multiplex assay in two exercise cohorts (Gene SMART and Hawaiian Ironman Triathlon).
- Analysis of endurance fitness parameters including peak power output, time trial performance, lactate threshold, and maximal oxygen uptake (VO2 max).
Main Results:
- 17 SNPs showed significant associations with performance gains (11 in Gene SMART, 6 in Hawaiian Ironman).
- The Interleukin 6 (IL6) variant rs1474347 was significantly associated with increased VO2 max gains post-training in the Gene SMART cohort (FDR < 0.05).
Conclusions:
- Genetic variance plays a role in modulating exercise training response.
- Genomic research can aid in assessing individual exercise trait responses and optimizing training regimens.
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