Topical application of St. John's wort (Hypericum perforatum)

Area of Science:

• Phytochemistry
• Dermatology
• Pharmacology

Background:

• St. John's wort (Hypericum perforatum) has a long-standing tradition in topical applications for various skin ailments.
• Its antidepressant properties are well-researched, but dermatological uses are also significant.
• Key constituents include naphthodianthrones (e.g., hypericin) and phloroglucinols (e.g., hyperforin).

Purpose of the Study:

• To review the dermatological applications of St. John's wort.
• To explore the pharmacological activities of its constituents relevant to skin health.
• To highlight the potential and current limitations of clinical research in this area.

Main Methods:

• Review of existing pharmacological and clinical studies on St. John's wort in dermatology.
• Analysis of the chemical constituents and their biological activities.
• Discussion of recent trials in wound healing, atopic dermatitis, psoriasis, and herpes simplex.

Main Results:

• Pharmacological research supports topical St. John's wort use for wounds, burns, and bruises.
• Hyperforin promotes keratinocyte growth; hypericin acts as a photosensitizer for skin cancer treatment.
• Antioxidant, anti-inflammatory, anticancer, and antimicrobial activities have been identified.

Conclusions:

• St. John's wort possesses significant potential for medical skin care due to its active compounds.
• Clinical evidence is still limited, necessitating further rigorous trials.
• Variability in pharmaceutical formulations requires careful consideration for practical and scientific use.