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[Usefulness of cystatin C as a prognostic marker in venous thromboembolism]

Ismael Calero-Paniagua1, Ana María Ruíz-Chicote2, José Antonio Nieto-Rodríguez3

  • 1Servicio de Reumatología, Hospital Universitario de Salamanca, Salamanca, España.

Medicina Clinica
|November 13, 2013
PubMed

Insights

Cystatin C (cysC) shows prognostic value in venous thromboembolism (VTE) patients, similar to creatinine but less than NT-proBNP. Elevated cysC levels at diagnosis predict a higher risk of death within six months.

Area of Science:

  • Cardiology
  • Nephrology
  • Hematology

Background:

  • Cystatin C (cysC) is a known prognostic marker in cardiovascular diseases.
  • Its prognostic utility in venous thromboembolism (VTE) requires further investigation.

Purpose of the Study:

  • To evaluate the prognostic value of cystatin C levels at diagnosis in patients with VTE.
  • To compare the prognostic accuracy of cysC with creatinine and NT-proBNP.

Main Methods:

  • A retrospective cohort study of 226 VTE patients followed for 6 months.
  • Serum levels of cysC, creatinine, and NT-proBNP were measured at diagnosis.

Main Results:

  • Cystatin C levels above 1.175 mg/dl were associated with a significantly higher risk of 6-month mortality (OR: 5.98, P<.001).
  • The prognostic accuracy of cysC was comparable to creatinine but lower than NT-proBNP.
  • No significant association was found between cysC levels and bleeding or recurrent VTE.

Conclusions:

  • Serum cystatin C concentration at diagnosis is a valuable prognostic marker in VTE patients.
  • Its predictive performance is similar to serum creatinine and inferior to NT-proBNP.
Abstract

Keywords:
Cistatina CCystatin CEnfermedad tromboembólica venosaMortalidadMortalityPrognosticPronósticoVenous thromboembolism

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