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Left and right ventricular structure and function in subclinical hypothyroidism: the effects of one-year

Sanja Ilic1, Marijana Tadic, Branislava Ivanovic

  • 1Department of Endocrinology, University Clinical Hospital Center "Dr Dragisa Misovic", Belgrade, Serbia.

Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
|November 13, 2013
PubMed

Insights

Subclinical hypothyroidism significantly impairs heart function and mechanics in both left and right ventricles. Levothyroxine treatment effectively improves cardiac structure and function in affected patients.

Area of Science:

  • Cardiology
  • Endocrinology
  • Medical Research

Background:

  • Subclinical hypothyroidism (SHT) is associated with cardiovascular changes.
  • Investigating cardiac structure and function in SHT is crucial.

Purpose of the Study:

  • To assess left ventricular (LV) and right ventricular (RV) structure, function, and mechanics in SHT patients.
  • To evaluate the impact of levothyroxine treatment on cardiac parameters in SHT.

Main Methods:

  • Comparison of 45 untreated SHT women with 35 healthy controls.
  • Laboratory analyses including thyroid hormone levels (free T3, free T4, TSH).
  • Complete 2-dimensional echocardiographic study and 1-year follow-up post-levothyroxine therapy.

Main Results:

  • SHT patients showed increased LV mass index and impaired LV systolic, diastolic, and global function (Tei index).
  • RV wall thickness was increased, with impaired RV diastolic and global function in SHT patients.
  • Levothyroxine therapy significantly improved LV and RV structure, function, and mechanics.

Conclusions:

  • Subclinical hypothyroidism detrimentally affects LV and RV structure, function, and mechanics.
  • Levothyroxine replacement therapy demonstrates significant benefits in restoring cardiac health in SHT patients.
Abstract

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