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Related Experiment Video

Updated: May 6, 2026

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Angiogenesis in multiple myeloma.

Angelo Vacca1, Roberto Ria, Antonia Reale

  • 1Department of Internal Medicine and Clinical Oncology and Department of Basic Medical Sciences, Neurosciences and Sensory Organs, University of Bari Medical School, and National Cancer Institute 'Giovanni Paolo II', Bari, Italy.

Chemical Immunology and Allergy
|November 13, 2013
PubMed
Summary
This summary is machine-generated.

Multiple myeloma progression relies on angiogenesis, driven by cancer cells and the bone marrow microenvironment. Understanding this interaction is key to targeting tumor growth and spread.

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Area of Science:

  • Oncology
  • Cell Biology
  • Pathophysiology

Background:

  • Angiogenesis is a critical factor in multiple myeloma (MM) progression and holds prognostic value.
  • MM cells interact extensively with host cells and the extracellular matrix, influencing the malignant phenotype.
  • Tumor microenvironment crosstalk is central to MM pathogenesis.

Purpose of the Study:

  • To elucidate the mechanisms of multiple myeloma-induced angiogenesis.
  • To investigate the role of host cells and the bone marrow microenvironment in MM neovascularization.
  • To understand the pathophysiological interplay between MM cells and their niche.

Main Methods:

  • Analysis of angiogenic cytokine production by plasma cells.
  • Investigation of host cell involvement (macrophages, mast cells) in vasculogenic mimicry.
  • Assessment of endothelial cell and precursor cell contributions to neovascularization.
  • Examination of extracellular matrix modifications within the tumor niche.

Main Results:

  • Multiple myeloma cells directly produce angiogenic cytokines.
  • Bone marrow macrophages and mast cells actively participate in vasculogenic mimicry.
  • Circulating and precursor endothelial cells contribute to MM neovascularization.
  • Significant crosstalk exists between MM cells and the bone marrow microenvironment.

Conclusions:

  • Angiogenesis is a fundamental aspect of multiple myeloma progression.
  • Host cells and the tumor microenvironment play crucial roles in MM-induced neovascularization.
  • Targeting the tumor microenvironment and angiogenesis pathways may offer therapeutic strategies for multiple myeloma.