Current status and new features of the Consensus Coding Sequence database.

Area of Science:

• Genomics
• Bioinformatics

Background:

• The Consensus Coding Sequence (CCDS) project is a collaborative effort to maintain a consistent dataset of protein-coding regions.
• It ensures identical annotations between human and mouse reference genomes from NCBI and Ensembl pipelines.
• CCDS IDs provide stable identifiers for these high-quality, quality-assured annotations.

Purpose of the Study:

• To describe the current status and growth of the CCDS dataset.
• To report recent enhancements to the CCDS web and FTP sites.
• To outline future curation targets for the CCDS project.

Main Methods:

• Collaborative review by NCBI, Wellcome Trust Sanger Institute, and UC Santa Cruz.
• Quality assurance tests for identical annotations.
• Development of new search, display, and reporting features on CCDS web and FTP sites.

Main Results:

• The CCDS dataset has experienced recent growth.
• Web and FTP sites now offer more explicit reporting on compared annotation releases.
• New features include improved search/display options and biologically descriptive information.

Conclusions:

• The CCDS project ensures high-quality, consistent genomic annotations.
• Recent updates enhance data usability and transparency for researchers.
• Ongoing curation efforts aim to further improve the CCDS dataset.