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YB-1 protein: functions and regulation
Dmitry N Lyabin1, Irina A Eliseeva, Lev P Ovchinnikov
1Institute of Protein Research, Russian Academy of Sciences, Pushchino, Moscow Region, Russia.
Wiley Interdisciplinary Reviews. RNA
|November 13, 2013
Summary
Y-box binding protein 1 (YB-1) is a versatile protein involved in DNA and RNA processes. Its disordered structure enables diverse functions in cell regulation, stress response, and cancer development.
Area of Science:
- Molecular Biology
- Genetics
- Cell Biology
Background:
- Y-box binding protein 1 (YB-1) is an intrinsically disordered protein.
- YB-1 possesses a conserved cold shock domain, indicating ancient evolutionary origins.
- Intrinsically disordered proteins challenge the 'one protein-one function' paradigm, suggesting multiple roles.
Purpose of the Study:
- To explore the diverse functions of YB-1.
- To highlight the link between YB-1's disordered structure and its multiple activities.
- To review YB-1's involvement in various cellular processes.
Main Methods:
- Literature review of studies on YB-1.
- Analysis of YB-1's molecular interactions with DNA and RNA.
- Examination of YB-1's role in cellular events.
Main Results:
- YB-1 participates in DNA repair, transcription, splicing, mRNA packaging, and translation regulation.
- YB-1 influences cell proliferation, differentiation, and stress responses.
- YB-1 is implicated in malignant cell transformation.
Conclusions:
- YB-1's intrinsically disordered nature underlies its multifaceted roles in cellular functions.
- YB-1 is a key regulator of gene expression and cellular processes.
- Further research into YB-1 could offer insights into disease mechanisms and therapeutic targets.
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