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The Isolation of Flowing Mesenteric Lymph in Mice to Quantify In Vivo Kinetics of Dietary Lipid Absorption and Chylomicron Secretion
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Intestinal cholesterol secretion: future clinical implications.

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The intestine plays a key role in cholesterol metabolism and reverse cholesterol transport (RCT). Direct trans-intestinal cholesterol excretion (TICE) is a newly identified pathway for cholesterol elimination, with potential therapeutic applications.

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Area of Science:

  • Cardiovascular Science
  • Metabolic Physiology
  • Gastroenterology

Background:

  • The intestine and liver are crucial for cholesterol homeostasis.
  • Reverse cholesterol transport (RCT) removes cholesterol from tissues to feces.
  • RCT in humans traditionally involves hepatobiliary excretion.

Purpose of the Study:

  • To review the emerging role of direct trans-intestinal cholesterol excretion (TICE) in cholesterol metabolism.
  • To discuss the potential of TICE as a therapeutic target for cardiovascular disease.

Main Methods:

  • This review synthesizes current research on TICE.
  • It examines evidence from mouse models and emerging human data.
  • The review discusses pharmacological and dietary interventions affecting TICE.

Main Results:

  • Direct trans-intestinal cholesterol excretion (TICE) significantly contributes to fecal neutral sterol (FNS) excretion in mice.
  • TICE can be modulated by pharmacological and dietary factors in mice.
  • Emerging evidence suggests TICE is relevant in human physiology and pathology.

Conclusions:

  • TICE represents a novel pathway for cholesterol elimination.
  • Targeting the intestine as an inducible cholesterol-excretory organ holds therapeutic promise.
  • Further research is needed to establish TICE's role in human cholesterol elimination and cardiovascular health.