Related Experiment Video
Updated: May 6, 2026

Microsurgical Skills of Establishing Permanent Jugular Vein Cannulation in Rats for Serial Blood Sampling of Orally Administered Drug
Published on: December 14, 2021
[Comparative study on pharmacokinetics of gentiopicroside and gentianae radix extract in rats]
Bo Feng1, He-Yun Zhu, Jiao Guan
1College of Pharmacy,Jilin Medical College, Jilin 132013, China. fengbo2@sina.com
Objective:
To compare the pharmacokinetics of gentiopicroside and Gentianae Radix extract in rats and assess the effect of other components in Gentianae Radix on the pharmacokinetics of gentiopicroside.
Methods:
The rats were oral administrated with gentiopicroside and Gentianae Radix extract, the content of geritiopicroside was chosen as index and determined by HPLC. The pharmacokinetic parameters were calculated with DAS 2.1.1 program.
Results:
The concentration-time curve of gentiopicroside and Gentianae Radix extract was described by two compartment model. The main pharmacokinetic parameters of gentiopicroside and Gentianae Radix extract were: C(max) (16.53 +/- 0.37) g/mL and (16.61 +/- 0.49) g/mL, T(max) 0.25 h and 1.5 h, t1/2(alpha) (0.20 +/- 0.04) h and (0.69 +/- 0. 14) h, t /2 (beta) (0.64 +/- 0.08) hand (0.80 +/- 0.11) h, AUC(0-infinity) (18.20 +/- 1.97) g x h/mL and (39.20 +/- 1.18) g x h/mL, CL( 2.75 +/- 0.32) L/(h x kg) and (1.22 +/- 0.04) L (h x kg), respectively.
Conclusion:
There are significantly differences in pharmacokinetic parameters between gentiopicroside and Gentianae Radix extract in rats.
More Related Videos
Related Concept Videos
Measurement of Bioavailability: Pharmacokinetic Methods
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption
Bioavailability Study Design: Single Versus Multiple Dose Studies
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism
Determination of Multiple Dosing Parameters: Steady-State, Minimum and Maximum Concentrations

