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Drug-induced impulse control disorders: a review.

Murad Atmaca1

  • 1Firat (Euphrates) Universitesi, Firat Tip Merkezi, Psikiyatri Anabilim Dali 23119, Elazig, Turkey. matmaca_p@yahoo.com.

Current Clinical Pharmacology
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This review examines drug-induced impulse control disorders, focusing on dopaminergic agents like cocaine, methamphetamine, and levodopa. These substances can trigger harmful impulsive behaviors, necessitating prompt clinical attention.

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Pharmacology

Background:

  • Impulse control disorders involve an inability to resist harmful impulses.
  • These disorders can arise independently of drug use, causing significant patient distress.
  • This review specifically addresses drug-induced impulsivity.

Purpose of the Study:

  • To review the role of various psychopharmacological agents in inducing impulse control disorders.
  • To focus on dopaminergic agents and their impact on the mesolimbic dopaminergic pathway.

Main Methods:

  • Literature review of articles from the PubMed database.
  • Search period: 1980 to August 2012.
  • Focus on psychopharmacological agents, particularly dopaminergic ones.

Main Results:

  • Dopaminergic agonists (e.g., cocaine, methamphetamine) are frequently implicated in drug-induced impulsivity.
  • Levodopa has a known association with triggering impulsive behaviors in Parkinson's disease patients.
  • The mesolimbic dopaminergic pathway is a key target for these agents.

Conclusions:

  • Certain psychopharmacological agents, especially dopaminergic drugs, can induce impulse control disorders.
  • Understanding these drug effects is crucial for managing patient adjustment and treatment.
  • Further research into drug-induced impulsivity is warranted.