Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Nociception01:44

Nociception

28.4K
Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain.
28.4K
Analgesia and Pain Management01:25

Analgesia and Pain Management

3.4K
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
3.4K
Pain01:20

Pain

2.1K
Pain serves as a critical warning signal that alerts the body to potential or actual harm. When mechanical pressure on the skin is intense, such as from a sharp pinch, the sensation transitions from touch to pain. Similarly, extreme temperatures, like a hot pot handle, convert the sensation of heat into pain. Pain can also result from overstimulation of other senses, such as blinding light, loud noise, or the intense heat from habañero peppers. This ability to sense pain is essential for...
2.1K
Local Anesthetics: Differential Sensitivity of Nerve Fibers01:24

Local Anesthetics: Differential Sensitivity of Nerve Fibers

1.8K
Local anesthetics (LAs) block the sodium channels of nerve trunks, sensory nerve endings, and neuromuscular junctions. Although LAs can block all kinds of nerves, the sensitivity of nerve fibers differs according to nerve types and structures. LAs are known to block myelinated fibers faster than unmyelinated ones. Also, they block pain or sensory neurons at low concentrations without affecting the motor neurons involved in muscle contractions. This helps relieve labor pain without affecting the...
1.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mind Matters: Integrating Psychological Insights Into Chronic Pelvic Pain Care.

Clinical obstetrics and gynecology·2026
Same author

Toward a Socioecological Understanding of Resilience in the Context of Chronic Pain.

Pain management nursing : official journal of the American Society of Pain Management Nurses·2026
Same author

Community-driven, culturally tailored interventions for MSK pain in Black/African Americans: A scoping review.

The journal of pain·2026
Same author

Chronic Overlapping Pain and Central Sensitization in Chronic Pelvic Pain: Do Positive and Negative Affect Play a Role?

Pain research & management·2026
Same author

Psychological and Clinical Risk Factors for Substance Use in People With and Without HIV.

Journal of the International Association of Providers of AIDS Care·2026
Same author

Pain Resilience and Catastrophizing as Mediators of Pain Intensity and Outcomes.

Pain management nursing : official journal of the American Society of Pain Management Nurses·2026
Same journal

Peer racial representation at school, social experiences, and inflammation among Black adolescents.

Health psychology : official journal of the Division of Health Psychology, American Psychological Association·2026
Same journal

Association of basal reproduction hormone status with the outcomes of controlled ovarian hyperstimulation: The moderating effect of psychological factors.

Health psychology : official journal of the Division of Health Psychology, American Psychological Association·2026
Same journal

Capturing wear in wear and tear: The negative-affect reactivity linked to discrimination is associated with biological age across two national samples of adults in the United States.

Health psychology : official journal of the Division of Health Psychology, American Psychological Association·2026
Same journal

Personality moderates immunological and functional consequences of caregiver burden.

Health psychology : official journal of the Division of Health Psychology, American Psychological Association·2026
Same journal

Daily-level associations between sleep hygiene, cannabis use, and sleep health outcomes.

Health psychology : official journal of the Division of Health Psychology, American Psychological Association·2026
Same journal

Clinically effective child change in family-based behavioral treatment for pediatric obesity: An individual participant mega-analysis.

Health psychology : official journal of the Division of Health Psychology, American Psychological Association·2026
See all related articles

Related Experiment Video

Updated: May 6, 2026

Dynamic Quantitative Sensory Testing to Characterize Central Pain Processing
09:16

Dynamic Quantitative Sensory Testing to Characterize Central Pain Processing

Published on: February 16, 2017

18.2K

Exploring pain processing differences in Native Americans.

Shreela Palit1, Kara L Kerr1, Bethany L Kuhn1

  • 1Department of Psychology.

Health Psychology : Official Journal of the Division of Health Psychology, American Psychological Association
|November 14, 2013
PubMed
Summary
This summary is machine-generated.

Native Americans exhibit reduced pain perception and spinal cord sensitization compared to non-Hispanic Whites. These findings suggest unique pain processing mechanisms that may require different chronic pain treatment strategies.

More Related Videos

Multi-Modal Signals for Analyzing Pain Responses to Thermal and Electrical Stimuli
09:16

Multi-Modal Signals for Analyzing Pain Responses to Thermal and Electrical Stimuli

Published on: April 5, 2019

11.4K
Determining heat and mechanical pain threshold in inflamed skin of human subjects
13:21

Determining heat and mechanical pain threshold in inflamed skin of human subjects

Published on: January 14, 2009

22.5K

Related Experiment Videos

Last Updated: May 6, 2026

Dynamic Quantitative Sensory Testing to Characterize Central Pain Processing
09:16

Dynamic Quantitative Sensory Testing to Characterize Central Pain Processing

Published on: February 16, 2017

18.2K
Multi-Modal Signals for Analyzing Pain Responses to Thermal and Electrical Stimuli
09:16

Multi-Modal Signals for Analyzing Pain Responses to Thermal and Electrical Stimuli

Published on: April 5, 2019

11.4K
Determining heat and mechanical pain threshold in inflamed skin of human subjects
13:21

Determining heat and mechanical pain threshold in inflamed skin of human subjects

Published on: January 14, 2009

22.5K

Area of Science:

  • Neuroscience
  • Pain Research
  • Health Disparities

Background:

  • Chronic pain conditions disproportionately affect Native Americans in the U.S.
  • Factors contributing to this health disparity in pain perception remain under-identified.

Purpose of the Study:

  • To investigate potential differences in pain processing between Native Americans and non-Hispanic White individuals.
  • To compare experimental pain measures, including pain thresholds, tolerance, and sensitization.

Main Methods:

  • Healthy Native American and non-Hispanic White participants were recruited.
  • Pain processing was evaluated using electrophysiological measures like the nociceptive flexion reflex (NFR) and subjective pain ratings.
  • Assessed electric and ischemia pain thresholds/tolerance, and temporal summation of pain and NFR.

Main Results:

  • Native Americans demonstrated significantly dampened pain perception compared to non-Hispanic Whites.
  • Higher pain tolerance and thresholds were observed in Native Americans.
  • Reduced temporal summation of NFR in Native Americans suggests decreased spinal cord sensitization.

Conclusions:

  • Native Americans may possess inherent mechanisms for reduced pain signaling, potentially involving enhanced descending pain inhibition.
  • These distinct pain processing characteristics in Native Americans contrast with other ethnic groups at risk for chronic pain.
  • The findings highlight the necessity for developing tailored interventions for chronic pain management in Native American populations.