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Related Experiment Videos

Amylase.

R Garrison

    Emergency Medicine Clinics of North America
    |May 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Elevated serum and urine amylase levels, or hyperamylasemia, often indicate pancreatitis or biliary tract disease. Differentiating causes requires serial testing and careful interpretation of laboratory results.

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    Area of Science:

    • Biochemistry
    • Clinical Chemistry
    • Diagnostic Medicine

    Background:

    • Serum and urine amylase activity tests are frequently ordered by emergency physicians.
    • Elevated amylase levels can signify various conditions, from normal physiology to emergent problems.
    • Depressed amylase levels are typically associated with chronic pancreatitis and pancreatic destruction.

    Purpose of the Study:

    • To explore the differential diagnosis of hyperamylasemia.
    • To evaluate the utility of serial and simultaneous serum and urine amylase measurements.
    • To address challenges in amylase testing interpretation.

    Main Methods:

    • Review of common laboratory requests for amylase activity.
    • Analysis of potential causes for elevated amylase levels.

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  • Discussion of laboratory methodologies and their limitations.

    • Main Results:

    • Hyperamylasemia is most commonly caused by pancreatitis and biliary tract disease.
    • Serial amylase determinations and simultaneous urine/serum assessments can aid in diagnosis.
    • Lack of a perfect test and varied laboratory procedures lead to confusion in units and reference ranges.

    Conclusions:

    • Interpreting hyperamylasemia requires considering a broad differential diagnosis.
    • Standard medical laboratories can perform amylase activity tests efficiently.
    • Isoenzyme fractionation is a specialized procedure not widely available.