Related Experiment Video

Updated: Aug 8, 2026

Assays for Studying the Role of Vitronectin in Bacterial Adhesion and Serum Resistance
10:55

Assays for Studying the Role of Vitronectin in Bacterial Adhesion and Serum Resistance

Published on: October 16, 2018

Homology with hemopexin suggests a possible scavenging function for S-protein/vitronectin

K K Stanley

    FEBS Letters
    |April 21, 1986
    PubMed

    S-protein is an abundant plasma protein which has recently been shown to be identical to vitronectin and serum spreading factor [(1985) EMBO J. 4, 3153-3157]. It therefore has multiple binding sites for terminal complement complexes, thrombin-antithrombin III, heparin, and a specific cell receptor. In this report a structural and sequence homology with hemopexin is described which suggests that the principle function of S-protein could be as a scavenging molecule, clearing spent complement and coagulation complexes from the circulation.

    More Related Videos

    Using a GFP-tagged TMEM184A Construct for Confirmation of Heparin Receptor Identity10:41

    Using a GFP-tagged TMEM184A Construct for Confirmation of Heparin Receptor Identity

    Published on: February 17, 2017

    Analysis of Group IV Viral SSHHPS Using In Vitro and In Silico Methods10:40

    Analysis of Group IV Viral SSHHPS Using In Vitro and In Silico Methods

    Published on: December 21, 2019

    Related Concept Videos

    Gene Families01:57

    Gene Families

    Gene families consist of groups of genes proposed to have originated from a common ancestor. Typically these arise through events in which a gene or genes are mistakenly duplicated during cell division. Unlike their parent genes (which are subject to selection pressure to maintain function), these gene copies do not need to preserve their sequences and may evolve at a relatively faster rate.
    Occasionally these regions can be adapted to take on new roles within the organism, becoming novel genes...
    Protein Families02:47

    Protein Families

    Protein families are groups of homologous proteins; that is, they have similarities in amino acid sequences and three-dimensional structures. Protein families usually occur because of gene duplication, where an additional copy of a gene is inserted into the genome of an organism.   Mutations that change the amino acids but still allow the protein to be properly synthesized, will lead to new protein family members.   If these new proteins contain similar amino acids in key locations, protein...
    Protein Complex Assembly02:41

    Protein Complex Assembly

    Proteins can form homomeric complexes with another unit of the same protein or heteromeric complexes with different types.  Most protein complexes self-assemble spontaneously via ordered pathways, while some proteins need assembly factors that guide their proper assembly. Despite the crowded intracellular environment, proteins usually interact with their correct partners and form functional complexes.
    Many viruses self-assemble into a fully functional unit using the infected host cell to...
    Conjugated Proteins02:50

    Conjugated Proteins

    Simple proteins and protein complexes contain only amino acids. In contrast, many other proteins, called conjugated proteins, covalently bond with non-protein moieties.
    Nucleoproteins are protein complexes that contain nucleic acids, categorized as deoxyribonucleoproteins (DNPs) or ribonucleoproteins (RNPs) respectively. The nucleosome is a typical example of a DNP where nuclear DNA is associated with histone proteins. The major antigen for the Covid-19 virus SARS-CoV is an RNP that is critical...
    Leaky Scanning02:28

    Leaky Scanning

    During most eukaryotic translation processes, the small 40S ribosome subunit scans an mRNA from its 5' end until it encounters the first start AUG codon. The large 60S ribosomal subunit then joins the smaller one to initiate protein synthesis. The location of the translation initiation is largely determined by the nucleotides near the start codon as there may be multiple translation initiation sites present on the mRNA.  Marilyn Kozak discovered that the sequence RCCAUGG (where R stands for...
    Exon Recombination02:32

    Exon Recombination

    The evolution of new genes is critical for speciation. Exon recombination, also known as exon shuffling or domain shuffling, is an important means of new gene formation. It is observed across vertebrates, invertebrates, and in some plants such as potatoes and sunflowers. During exon recombination, exons from the same or different genes recombine and produce new exon-intron combinations, which might evolve into new genes. 
    Exon shuffling follows “splice frame rules.” Each exon has three reading...