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Propofol alleviates intractable migraine headache: a case report
Masood Mohseni1, Farzad Fatehi
1Department of Anesthesiology, Rasoul Akram Medical Center, Iran University of Medical Sciences (IUMS), Tehran, IR Iran.
Anesthesiology and Pain Medicine
|November 14, 2013
Summary
Intravenous propofol offers rapid migraine relief for patients unresponsive to standard treatments. Subanesthetic doses may represent a novel therapeutic option for acute migraine attacks.
Area of Science:
- Neurology
- Pharmacology
Background:
- Migraine attacks pose significant challenges due to limited efficacy and side effects of first-line oral medications.
- Nausea and vomiting in some patients further complicate oral drug administration.
Observation:
- A patient experiencing a severe migraine attack, refractory to metoclopramide, promethazine, dexamethasone, and meperidine, was treated.
- Intravenous administration of 60 mg of propofol resulted in dramatic pain relief.
Findings:
- Subanesthetic doses of propofol demonstrated significant efficacy in managing an acute, treatment-refractory migraine attack.
- This case adds to previous reports suggesting propofol's potential as an alternative migraine treatment.
Implications:
- Intravenous propofol may be a viable alternative for acute migraine management, particularly in cases resistant to conventional therapies.
- Further research into subanesthetic propofol dosing for migraine is warranted to establish its safety and efficacy profile.
