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Updated: May 6, 2026

Intracortical Inhibition Within the Primary Motor Cortex Can Be Modulated by Changing the Focus of Attention

Intracortical Inhibition Within the Primary Motor Cortex Can Be Modulated by Changing the Focus of Attention

Published on: September 11, 2017

Preparing for selective inhibition within frontostriatal loops.

Peter Smittenaar¹, Marc Guitart-Masip, Antoine Lutti

¹Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, 12 Queen Square, WC1N 3BG, London, United Kingdom.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience

|November 15, 2013

Summary

This summary is machine-generated.

Preparing for selective action inhibition improves speed and accuracy. However, individual differences reveal a trade-off between stopping speed and selectivity, implemented in frontostriatal brain regions.

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Last Updated: May 6, 2026

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Online Transcranial Magnetic Stimulation Protocol for Measuring Cortical Physiology Associated with Response Inhibition

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Published on: February 8, 2018

Area of Science:

Cognitive Neuroscience
Neuroscience
Motor Control

Background:

Action inhibition allows for global motor output suppression or selective cancellation of specific actions during concurrent tasks.
Understanding the mechanisms of selective inhibition, particularly the role of preparation, is crucial for cognitive control research.

Purpose of the Study:

To investigate the behavioral and neural underpinnings of selective action inhibition.
To examine the influence of preparation on the speed and selectivity of inhibition.
To identify the neural correlates and individual differences associated with proactive selective inhibition.

Main Methods:

Utilized functional magnetic resonance imaging (fMRI) in 18 healthy human participants.
Manipulated preparation for selective inhibition by providing or withholding information about potential actions to be stopped.
Analyzed behavioral data for inhibition speed and selectivity, and fMRI data for neural engagement.

Main Results:

Preparation for selective inhibition significantly improved both the speed and selectivity of stopping actions.
fMRI data revealed engagement of the inferior frontal gyrus, supplementary motor area, and striatum during preparation for selective inhibition.
Individual differences showed a trade-off between inhibition speed and selectivity, linked to the dorsolateral prefrontal cortex and putamen engagement.

Conclusions:

Proactive selective action inhibition is primarily implemented within frontostriatal brain networks.
A speed-selectivity trade-off in inhibition may explain previously observed variations in cognitive control research findings.