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Published on: April 1, 2019
CTLA-4 gene polymorphisms and susceptibility to chronic obstructive pulmonary disease
Lijing Deng1, Haixia Zhou, Jing Yang
1Department of Intensive Care Unit, West China Hospital, Sichuan University Chengdu, Sichuan Province, China.
Objective:
The aim of this study was to investigate whether four single nucleotide polymorphisms (SNPs) in CTLA-4 gene are associated with chronic obstructive pulmonary disease (COPD) in a Chinese population.
Methods:
Samples were collected from a Chinese population and analyzed for the association of SNPs in CTLA-4 gene with COPD in a case-control study. Four SNPs (rs231775, rs3087243, rs231725, rs5742909) in CTLA-4 gene were chosen and genotyped. The results were then analyzed using statistical methods.
Results:
We found that none of these four SNPs (rs231775, rs3087243, rs231725, rs5742909) in CTLA-4 gene were associated with the disease.
Conclusion:
Our data suggested that there was no significant association between these four SNPs in CTLA-4 gene and COPD susceptibility in a Chinese population.
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