Related Experiment Video
Updated: May 6, 2026
06:12
Author Spotlight: THP-1 Macrophage Response to LPS/ATP — Unveiling the Pyroptosis, Apoptosis, and Necroptosis Spectrum
Published on: May 3, 2024
3.4K
[Necroptosis: a programmed cell necrosis]
1Dept of Pharmacology, College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, China.
Sheng Li Ke Xue Jin Zhan [Progress in Physiology]
|November 16, 2013
Summary
Necroptosis, a regulated form of cell death, involves receptor-interacting protein (RIP1) and RIP3 signaling. Understanding these pathways is key to exploring roles in organ injury, inflammation, and cancer.
Area of Science:
- Molecular Biology
- Cell Biology
- Pathology
Background:
- Cell death is fundamental to life.
- Necroptosis, a distinct form of regulated cell death, shares traits with necrosis but follows specific signaling routes.
- Receptor-interacting protein 1 (RIP1) and RIP3 are central to necroptosis.
Purpose of the Study:
- To summarize current knowledge on necroptosis signaling pathways.
- To briefly explore the role of necroptosis in organ ischemic injury, inflammation, and tumor pathogenesis.
Main Methods:
- Literature review of necroptosis signaling pathways.
- Analysis of the roles of RIP1 and RIP3 in cell death decisions.
- Exploration of necroptosis involvement in disease pathogenesis.
Main Results:
- Necroptosis is a regulated cell death pathway.
- RIP1 and RIP3 interactions are critical for necroptosis.
- RIP1 influences cell survival and death decisions, while RIP3 directs the cell fate towards apoptosis or necrosis.
Conclusions:
- Necroptosis signaling pathways are complex and crucial.
- Dysregulation of necroptosis is implicated in organ ischemic injury, inflammation, and cancer development.
Related Concept Videos
01:16Necrosis
5.3K
Necrosis is considered as an “accidental” or unexpected form of cell death that ends in cell lysis. The first noticeable mention of “necrosis” was in 1859 when Rudolf Virchow used this term to describe advanced tissue breakdown in his compilation titled “Cell Pathology”.
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become...
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become...
5.3K
01:30Overview of Cell Death
7.7K
Cell death is an essential process where the body gets rid of old or damaged cells. Cell proliferation and death need to be balanced, as an imbalance between the two may lead to cancer or autoimmune diseases.
Cell death was observed in the early 19th century, but there was no experimental evidence to prove it. In 1842, Carl Vogt first discovered cell death in a metamorphic toad; however, it was not termed ‘cell death.’ Scientists discovered different cell death pathways only in the...
Cell death was observed in the early 19th century, but there was no experimental evidence to prove it. In 1842, Carl Vogt first discovered cell death in a metamorphic toad; however, it was not termed ‘cell death.’ Scientists discovered different cell death pathways only in the...
7.7K
01:16Cellular Injury IV: Necrosis
97
Necrosis is a form of irreversible cell death caused by severe injury such as ischemia, toxins, or trauma. Unlike programmed cell death, it is an uncontrolled, pathological process that typically provokes inflammation in surrounding tissues.Pathophysiologic ChangesNecrosis begins when cells sustain critical damage, leading to swelling of organelles, particularly mitochondria, and rapid ATP depletion. As energy levels decline, membrane ion pumps fail, leading to calcium influx and eventually,...
97
01:30Apoptosis
12.2K
Apoptosis is a combination of two Greek words, 'apo' and 'ptosis,' meaning separation and falling off, respectively. Hippocrates used this word to describe gangrene, which was caused due to bandaging of fractured bones. Apoptosis was distinguished from necrosis in 1970 when John Kerr reported observations of morphological changes occurring during apoptosis. During one experiment, he observed that the disruption of blood supply to the liver tissue resulted in a size...
12.2K
01:18Autophagic Cell Death
3.3K
Christian de Duve discovered “autophagy,” a process in which cellular components are engulfed by membrane-bound organelles called autophagosomes. The autophagosomes then fuse with lysosomes to digest the enclosed contents. Autophagy is generally activated in cells to prevent cell death. However, cell death is triggered when the damage is beyond repair.
Autophagy and Apoptosis
Autophagy can activate apoptosis. In normal conditions, the autophagy activating protein Beclin-1 and...
Autophagy and Apoptosis
Autophagy can activate apoptosis. In normal conditions, the autophagy activating protein Beclin-1 and...
3.3K
01:11Cellular Injury IlI: Cellular Death
93
Cell death is the irreversible loss of cellular structure and function, representing the final stage of severe injury. It plays a key role in both normal physiology and disease.Types of Cell DeathThe two main types are necrosis and apoptosis, though others like necroptosis and pyroptosis also exist.Necrosis:Necrosis is an unregulated form of cell death caused by severe injury such as trauma, toxins, or ischemia. It is characterized by cell swelling, membrane loss, rupture, and leakage of...
93