Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Na+,K+-ATPase: structure, function, and interactions with drugs.

W L Stahl, W E Harris

    Advances in Neurology
    |January 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    An investigation into the impact of nine catchment characteristics on the accuracy of two phosphorus load apportionment models.

    Environmental monitoring and assessment·2021
    Same author

    A global assessment of the social and conservation outcomes of protected areas.

    Conservation biology : the journal of the Society for Conservation Biology·2015
    Same author

    A pocket-sized disposable device for testing the integrity of sensation in the outpatient setting.

    Diabetic medicine : a journal of the British Diabetic Association·2012
    Same author

    An emergent science on the brink of irrelevance: a review of the past 8 years of DNA barcoding.

    Molecular ecology resources·2012
    Same author

    The polarography of uranium; polarography in strongly acid solution.

    Journal of the American Chemical Society·2010
    Same author

    Early contributions to the neurochemistry of sodium and potassium transport.

    Neurochemistry international·2010
    Same journal

    Future and alternative therapies in Tourette syndrome.

    Advances in neurology·2006
    Same journal

    Behavioral neurosurgery.

    Advances in neurology·2006
    Same journal

    Behavior therapy: other interventions for tic disorders.

    Advances in neurology·2006
    Same journal

    Behavioral treatments for tic suppression: habit reversal training.

    Advances in neurology·2006
    Same journal

    Treatment of aggression in Tourette syndrome.

    Advances in neurology·2006
    Same journal

    Treatment of co-morbid obsessive compulsive disorder, mood, and anxiety disorders.

    Advances in neurology·2006
    See all related articles

    Na+,K+-ATPase is vital for nervous system ion balance. Its role in epilepsy and glial cells is debated, with research focusing on its structure and drug interactions, like phenytoin

    Area of Science:

    • Neuroscience
    • Biochemistry
    • Molecular Biology

    Background:

    • Na+,K+-ATPase is crucial for maintaining sodium, potassium, and calcium ion homeostasis in the nervous system.
    • Its role in epilepsy and glial cell function, particularly in regulating extracellular potassium, is a subject of ongoing debate.
    • Current research aims to elucidate the structure and drug-binding sites of Na+,K+-ATPase.

    Purpose of the Study:

    • To review the role of Na+,K+-ATPase in nervous system homeostasis and epilepsy.
    • To address the controversial role of Na+,K+-ATPase in glial cells.
    • To highlight research on Na+,K+-ATPase structure, drug interactions, and membrane effects.

    Main Methods:

    • Review of immunocytochemical and histochemical studies.

    Related Experiment Videos

  • Analysis of research on Na+,K+-ATPase activity in epileptic tissue.
  • Investigation of drug interactions using fluorescent probes.

    • Main Results:

    • Evidence generally does not support high Na+,K+-ATPase concentrations in glial cells.
    • Phenytoin demonstrates a significant membrane-fluidizing effect, potentially linked to intrinsic membrane proteins.
    • Transitory changes in Na+,K+-ATPase activity in epileptic tissue may be secondary effects.

    Conclusions:

    • The precise role of Na+,K+-ATPase in epilepsy and glial function requires further investigation.
    • Understanding Na+,K+-ATPase structure and drug interactions is critical for therapeutic development.
    • Phenytoin's membrane-fluidizing action highlights potential mechanisms of drug action on ion transport proteins.