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[Association between vitamin D receptor gene polymorphisms and pediatric Crohn's disease in China: a study based on

You-You Luo1, Xiao-Li Shu, Hong Zhao

  • 1Department of Gastroenterology, Children's Hospital of Zhejiang University, School of Medicine, Hangzhou 310003, China. hzcjie@zju.edu.cn.

Zhongguo Dang Dai Er Ke Za Zhi = Chinese Journal of Contemporary Pediatrics
|November 16, 2013
PubMed

Insights

Pediatric Crohn's disease (CD) patients in China exhibit lower serum vitamin D levels. However, specific vitamin D receptor (VDR) gene polymorphisms (TaqI, BsmI, ApaI) do not appear to be associated with CD susceptibility in this population.

Area of Science:

  • Genetics
  • Immunology
  • Pediatrics

Context:

  • Crohn's disease (CD) is a chronic inflammatory bowel disease affecting children.
  • Vitamin D deficiency is common in CD patients.
  • Vitamin D receptor (VDR) gene polymorphisms may influence disease susceptibility.

Purpose:

  • To examine the relationship between VDR gene polymorphisms (TaqI, BsmI, ApaI) and pediatric CD in China.
  • To compare serum 25-hydroxyvitamin D3 [25(OH)D3] levels between pediatric CD patients and healthy controls.

Summary:

  • This study analyzed 19 pediatric CD cases and 122 healthy controls in China.
  • Serum 25(OH)D3 levels were significantly lower in children with CD compared to controls.
  • No significant differences were found in the genotype or allele frequencies of VDR gene polymorphisms (TaqI, BsmI, ApaI) between the groups.

Impact:

  • Findings suggest that low serum vitamin D levels are associated with pediatric CD in China.
  • The studied VDR gene polymorphisms may not be a significant genetic factor for CD susceptibility in the Chinese pediatric population.
  • Further research is needed to explore other genetic and environmental factors contributing to pediatric CD.
Abstract

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