Related Experiment Video

Updated: May 6, 2026

A Blood-based Test for the Detection of ROS1 and RET Fusion Transcripts from Circulating Ribonucleic Acid Using Digital Polymerase Chain Reaction
10:35

A Blood-based Test for the Detection of ROS1 and RET Fusion Transcripts from Circulating Ribonucleic Acid Using Digital Polymerase Chain Reaction

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[Significances of RET fusion gene in non-small cell lung cancer]

Jingjing Liu1, Minghong Bi

  • 1Department of Medical Oncology, the First Affiliated Hospital of Bengbu Medical University, Bengbu 233004, China.

Zhongguo Fei AI Za Zhi = Chinese Journal of Lung Cancer
|November 16, 2013
PubMed

Insights

RET fusion genes are key targets in non-small cell lung cancer (NSCLC) treatment. Targeting these RET fusions with specific inhibitors offers a promising approach for personalized NSCLC therapy.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Context:

  • Lung cancer remains a leading cause of cancer mortality globally.
  • Molecular targeted therapy is a significant area of research for non-small cell lung cancer (NSCLC).
  • RET fusion genes present distinct clinical and pathological features in specific lung cancer subsets.

Purpose:

  • To review the structural characteristics of RET fusion genes.
  • To examine the expression models of RET fusion genes in clinical samples.
  • To discuss the therapeutic implications of targeting RET fusions in NSCLC.

Summary:

  • RET fusion genes are identified in subsets of NSCLC patients.
  • Effective treatment is achievable using RET inhibitors for tumors with these fusions.
  • This suggests RET fusion genes are a viable target for individualized NSCLC treatment strategies.

Impact:

  • Highlights RET fusion genes as a potential biomarker for personalized NSCLC therapy.
  • Emphasizes the efficacy of RET inhibitors in a specific NSCLC subgroup.
  • Provides insights into the structural and expression patterns of RET fusions relevant to clinical application.

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