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Histone H3.3 mutations: a variant path to cancer

Benjamin T K Yuen1, Paul S Knoepfler

  • 1Department of Cell Biology and Human Anatomy, University of California Davis School of Medicine, 4303 Tupper Hall, Davis, CA 95616, USA; Genome Center, University of California Davis School of Medicine, 451 Health Sciences Drive, Davis, CA 95616, USA; Institute of Pediatric Regenerative Medicine, Shriners Hospital For Children Northern California, 2425 Stockton Boulevard, Sacramento, CA 95817, USA.

Cancer Cell
|November 16, 2013
PubMed
Summary

Mutant histone H3.3 (histone 3 variant 3) promotes pediatric brain cancers by disrupting epigenetic modifications. These histone changes also broadly contribute to human cancer development.

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