Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Diabetes: Management and Pharmacotherapy01:15

Diabetes: Management and Pharmacotherapy

1.5K
The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
1.5K
Diabetes Mellitus: Introduction01:26

Diabetes Mellitus: Introduction

56
Diabetes mellitus consists of chronic metabolic disorders characterized by persistent hyperglycemia. This elevated blood glucose results from defects in insulin secretion, impaired insulin action, or both. Insulin, produced by pancreatic β-cells, is essential for maintaining glucose homeostasis by facilitating cellular glucose uptake for energy or storage. Disruptions in insulin production or function lead to glucose accumulation in the bloodstream, causing the clinical features and...
56
Diabetes: Symptoms, Diagnosis, and Complications01:15

Diabetes: Symptoms, Diagnosis, and Complications

2.5K
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
2.5K
Type II Diabetes I: Introduction01:26

Type II Diabetes I: Introduction

57
Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by insulin resistance, in which target tissues such as the liver, muscle, and adipose tissue respond poorly to insulin. It is also associated with inadequate compensatory insulin secretion, where pancreatic β-cells fail to produce sufficient insulin. Together, these abnormalities lead to persistent hyperglycemia.EtiologyT2DM develops through a complex interaction of genetic predisposition and environmental or...
57
Type II Diabetes Mellitus III: Clinical Manifestations and Diagnosis01:25

Type II Diabetes Mellitus III: Clinical Manifestations and Diagnosis

32
Type 2 diabetes mellitus develops gradually and is often asymptomatic in early stages.Clinical ManifestationsWhen symptoms appear, they include fatigue, blurred vision, pruritus, delayed wound healing, and recurrent infections, particularly candidal infections. Peripheral neuropathy may present as numbness or tingling in the extremities. Classic hyperglycemia symptoms—polyuria, polydipsia, and polyphagia—are less common. Most patients are overweight and frequently have associated...
32
Type II Diabetes II: Pathophysiology01:24

Type II Diabetes II: Pathophysiology

36
PathophysiologyType 2 diabetes mellitus (T2DM ) is a chronic metabolic disorder characterized by insulin resistance and progressive pancreatic β-cell dysfunction, leading to impaired glucose homeostasis. It results from interactions among genetic predisposition, environmental factors, and metabolic stressors, such as overnutrition and a sedentary lifestyle.Insulin Resistance and Glucose DysregulationEarly T2DM involves insulin resistance in skeletal muscle, adipose tissue, and the liver.
36

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Absence of item origin bias on a Brazilian interinstitutional Progress Test examination: A pooled analysis of items approach.

PloS one·2025
Same author

Reliability across content areas in progress tests assessing medical knowledge: a Brazilian cross-sectional study with implications for medical education assessments.

Sao Paulo medical journal = Revista paulista de medicina·2024
Same author

InsuOnline, an Electronic Game for Medical Education on Insulin Therapy: A Randomized Controlled Trial With Primary Care Physicians.

Journal of medical Internet research·2017
Same author

User Assessment of "InsuOnLine," a Game to Fight Clinical Inertia in Diabetes: A Pilot Study.

Games for health journal·2015
Same author

Gaming Habits and Opinions of Brazilian Medical School Faculty and Students: What's Next?

Games for health journal·2015
Same author

InsuOnline, a Serious Game to Teach Insulin Therapy to Primary Care Physicians: Design of the Game and a Randomized Controlled Trial for Educational Validation.

JMIR research protocols·2013

Related Experiment Video

Updated: May 6, 2026

A Zebrafish Model of Diabetes Mellitus and Metabolic Memory
10:03

A Zebrafish Model of Diabetes Mellitus and Metabolic Memory

Published on: February 28, 2013

25.3K

[Diabetes: time to redefine goals?].

Leandro Arthur Diehl

    Arquivos Brasileiros De Endocrinologia E Metabologia
    |November 16, 2013
    PubMed
    Summary

    The Brazilian Diabetes Society's (SBD) blood glucose targets are incompatible with their A1c goals, potentially leading to suboptimal diabetes management. Reviewing these targets is crucial for clearer therapeutic recommendations.

    Area of Science:

    • Endocrinology
    • Metabolic Diseases
    • Clinical Research

    Background:

    • The Brazilian Diabetes Society (SBD) provides guidelines for diabetes management, including targets for both glycated hemoglobin A1c (HbA1c) and blood glucose levels.
    • Inconsistencies in clinical guidelines can lead to confusion and suboptimal patient outcomes in diabetes care.

    Purpose of the Study:

    • To evaluate the compatibility between the A1c targets and blood glucose goals set by the Brazilian Diabetes Society (SBD).
    • To determine if the recommended blood glucose levels align with the desired A1c outcomes in diabetes management.

    Main Methods:

    • Utilized the AIDA online simulation tool to model a hypothetical patient.
    • Simulated blood glucose values based on SBD's recommended targets (fasting < 100 mg/dL, preprandial < 110 mg/dL, postprandial < 140 mg/dL).

    More Related Videos

    Improving IV Insulin Administration in a Community Hospital
    12:08

    Improving IV Insulin Administration in a Community Hospital

    Published on: June 11, 2012

    19.7K
    A Method for Manipulating Blood Glucose and Measuring Resulting Changes in Cognitive Accessibility of Target Stimuli
    08:01

    A Method for Manipulating Blood Glucose and Measuring Resulting Changes in Cognitive Accessibility of Target Stimuli

    Published on: August 12, 2016

    8.8K

    Related Experiment Videos

    Last Updated: May 6, 2026

    A Zebrafish Model of Diabetes Mellitus and Metabolic Memory
    10:03

    A Zebrafish Model of Diabetes Mellitus and Metabolic Memory

    Published on: February 28, 2013

    25.3K
    Improving IV Insulin Administration in a Community Hospital
    12:08

    Improving IV Insulin Administration in a Community Hospital

    Published on: June 11, 2012

    19.7K
    A Method for Manipulating Blood Glucose and Measuring Resulting Changes in Cognitive Accessibility of Target Stimuli
    08:01

    A Method for Manipulating Blood Glucose and Measuring Resulting Changes in Cognitive Accessibility of Target Stimuli

    Published on: August 12, 2016

    8.8K
  • Calculated average glucose and converted it to A1c using the American Diabetes Association (ADA) online calculator.

    • Main Results:

    • The SBD's blood glucose goals correlated with an estimated A1c of 5.9%.
    • This calculated A1c is significantly lower than the SBD's recommended A1c goal of 7%.
    • The findings indicate a clear incompatibility between the SBD's proposed blood glucose and A1c targets.

    Conclusions:

    • The SBD's current recommendations present conflicting targets for A1c and blood glucose management.
    • There is a need for the SBD to revise its guidelines, ensuring blood glucose goals are compatible with A1c targets.
    • Clarifying therapeutic objectives is essential for effective diabetes treatment and improved patient outcomes.