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2° Amines to N-Nitrosamines: Reaction with NaNO2

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Updated: May 5, 2026

A Simple Method for Automated Solid Phase Extraction of Water Samples for Immunological Analysis of Small Pollutants

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Published on: January 1, 2016

N-nitrosodimethylamine in drinking water using a rapid, solid-phase extraction method.

S W Jenkins¹, C J Koester, V Y Taguchi

¹Ministry of Environment and Energy, Laboratory Services Branch, 125 Resources Road, M9P 3V6, Etobicoke, Ontario, Canada.

Environmental Science and Pollution Research International

|November 16, 2013

Summary

This summary is machine-generated.

A new method using Ambersorb 572 efficiently extracts N-nitrosodimethylamine (NDMA) from water. This faster, greener technique significantly reduces solvent use and boosts productivity for water quality monitoring.

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Area of Science:

Environmental Chemistry
Analytical Chemistry

Background:

Regulatory guidelines for N-nitrosodimethylamine (NDMA) in drinking water (9 ppt) and effluents (200 ppt) necessitate efficient analytical methods.
Traditional liquid-liquid extraction methods are labor-intensive and generate significant solvent waste.

Purpose of the Study:

To develop a simple, rapid, and environmentally friendly method for NDMA extraction from water samples.
To improve analytical throughput and reduce solvent consumption compared to existing techniques.

Main Methods:

Utilized Ambersorb 572, a granular adsorbent, for the solid-phase extraction of NDMA directly from water samples.
Eluted NDMA from Ambersorb 572 using dichloromethane within an autosampler vial for subsequent analysis.

Main Results:

Achieved high precision (4% replicate analyses) and accuracy (6% at 10 ppt) with a low detection limit of 1.0 ppt NDMA.
Demonstrated excellent agreement with liquid-liquid extraction (12% average difference).
Reduced dichloromethane usage by 1,000-fold and increased productivity by 3-4 times.

Conclusions:

The Ambersorb 572 method provides a robust, efficient, and sustainable alternative for NDMA analysis in various water matrices.
This method supports effective monitoring of NDMA levels to meet stringent regulatory requirements and assess drinking water quality.