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Updated: May 5, 2026

Preparation, Purification, and Use of Fatty Acid-containing Liposomes
Published on: February 9, 2018
Medium-chain sugar amphiphiles: a new family of healthy vegetable oil structuring agents
Swapnil R Jadhav1, Hyeondo Hwang, Qingrong Huang
1Department of Chemistry, The City College of New York, and The Graduate School and University Center of The City University of New York , 160 Convent Avenue, New York, New York 10031, United States.
Abstract:
Vegetable oils are frequently structured to enhance their organoleptic and mechanical properties. This is usually achieved by increasing the net amount of saturated and/or trans fatty acids in the oil. With the risk of coronary heart diseases associated with these fatty acids, the food industry is looking for better alternatives. In this context, the medium-chain dialkanoates of low-calorie sugars (sugar alcohol dioctanoates) are investigated as a healthy alternative structuring agent. Precursors of sugar amphiphiles, being FDA-approved GRAS materials, exhibited high cell viability at a concentration ~50 μg/mL. They readily formed nanoscale multilayered structures in an oil matrix to form a coherent network at low concentrations (1-3 wt %/v), which immobilized a wide range of oils (canola, soybean, and grapeseed oils). The structuring efficiency of sugar amphiphiles was computed in terms of mechanical, thermal, and structural properties and found to be a function of its type and concentration.
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