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Pediatric thrombophilia

Janet Y K Yang1, Anthony K C Chan

  • 1Division of Hematology and Oncology, Department of Pediatrics, McMaster University, 1280 Main Street West, Hamilton, Ontario L8S 4K1, Canada.

Pediatric Clinics of North America
|November 19, 2013
PubMed

Insights

Pediatric thrombosis (blood clots) and thrombophilia (clotting disorders) are rising health concerns in children. This review categorizes risk factors and outlines testing strategies for pediatric blood clot conditions.

Area of Science:

  • Pediatric Hematology
  • Thrombosis Research
  • Clinical Pediatrics

Background:

  • Pediatric thrombosis and thrombophilia are increasingly recognized clinical issues.
  • Understanding risk factors is crucial for diagnosis and management.
  • Virchow's triad provides a framework for analyzing thrombosis causes.

Purpose of the Study:

  • To categorize inherited and acquired factors contributing to pediatric thrombosis.
  • To describe the indications and rationale for thrombophilia testing in children.
  • To provide guidance on testing protocols and contraceptive recommendations.

Main Methods:

  • Review and categorization of risk factors based on Virchow's triad (stasis, hypercoagulable state, vascular injury).
  • Analysis of current literature on thrombophilia testing in pediatric populations.
  • Synthesis of recommendations for testing and management.

Main Results:

  • Identified inherited and acquired risk factors for thrombosis in neonates and children.
  • Detailed the rationale and indications for performing thrombophilia testing.
  • Outlined comprehensive guidance on who, how, when, and why to conduct testing.

Conclusions:

  • Effective management of pediatric thrombosis requires understanding diverse risk factors.
  • Standardized thrombophilia testing protocols are essential for accurate diagnosis.
  • Informed recommendations regarding contraceptives are necessary for at-risk adolescent females.

Keywords:
Arterial ischemic strokeCerebral sinus venous thrombosisPediatric thrombosisThrombophiliaVenous thromboembolic event

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