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Compensatory cellular hypertrophy: the other strategy for tissue homeostasis
Yoichiro Tamori1, Wu-Min Deng1
1Department of Biological Science, Florida State University, Tallahassee, FL 32306-4295, USA.
Trends in Cell Biology
|November 19, 2013
Summary
Metazoan tissues can grow larger without cell division through compensatory cellular hypertrophy (CCH). This conserved mechanism aids tissue repair and development in various species.
Area of Science:
- Cell Biology
- Developmental Biology
- Tissue Homeostasis
Background:
- Metazoan tissues maintain size and eliminate damaged cells through tissue homeostasis.
- Cell division is the primary mechanism for growth and repair.
- Recent findings reveal alternative growth strategies in postmitotic tissues.
Purpose of the Study:
- To highlight the phenomenon of compensatory cellular hypertrophy (CCH).
- To discuss the underlying mechanisms driving CCH.
- To emphasize CCH as an evolutionarily conserved strategy.
Main Methods:
- Review of recent studies in Drosophila.
- Analysis of compensatory cellular hypertrophy in various contexts.
- Discussion of underlying molecular and cellular mechanisms.
Main Results:
- Cells in postmitotic tissues can undergo hypertrophic growth without division.
- Compensatory cellular hypertrophy (CCH) contributes to tissue repair and organ development.
- CCH is observed in diverse cell types, including mammalian hepatocytes and corneal endothelial cells.
Conclusions:
- Compensatory cellular hypertrophy (CCH) is a significant strategy for tissue growth.
- CCH is likely an evolutionarily conserved mechanism across metazoans.
- Understanding CCH provides insights into tissue repair and organ development.
Keywords:
Drosophila follicle cellscell competitioncompensatory cellular hypertrophycompensatory proliferationpostmitotic tissuetissue homeostasisMore Related Videos
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