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Context-specific BAFF-R signaling by the NF-κB and PI3K pathways

Julia Jellusova1, Ana V Miletic, Matthew H Cato

  • 1Program on Inflammatory Diseases, Infectious and Inflammatory Diseases Center, Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.

Cell Reports
|November 19, 2013
PubMed
Summary

B cell maturation and survival depend on BAFF signaling through IKK1 and PI3K pathways. Combined inactivation of CD19 and IKK1 severely blocks B cell development, highlighting their critical roles.

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