The prostate cancer genome: perspectives and potential
Christopher E Barbieri1, Scott A Tomlins2
1Department of Urology, Weill Medical College of Cornell University, New York, NY; Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, New York, NY.
Urologic Oncology
|November 19, 2013
Summary
Prostate cancer
Area of Science:
- Genomic research in oncology
- Molecular pathology of cancer
Background:
- Prostate cancer exhibits significant clinical variability.
- Genomic heterogeneity contributes to unpredictable disease behavior.
Purpose of the Study:
- To review genomic alterations in prostate cancer.
- To explore their diagnostic and prognostic potential.
Main Methods:
- Literature review focusing on somatic alterations in prostate cancer.
Main Results:
- Common tumorigenesis pathways (PI3K, cell cycle, chromatin regulation) are dysregulated.
- Prostate cancer-specific alterations include androgen signaling, ETS gene fusions, and SPOP mutations.
- Molecular profiling can subdivide prostate cancer based on genetic alterations.
Conclusions:
- Prostate cancer may be classified into molecular subtypes.
- These subtypes could have distinct risk profiles and therapeutic strategies.
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