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Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
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Development and Application of MiMouse, a Comprehensive Genomic Profiling Panel for Credentialing Mouse Tumor Models.

Kevin Hu1, Chia-Jen Liu2, Zhaoping Qin3

  • 1Department of Computational Medicine & Bioinformatics, University of Michigan Medical School, Ann Arbor, Michigan.

Cancer Research Communications
|October 6, 2025
PubMed
Summary
This summary is machine-generated.

We developed MiMouse, a comprehensive genomic profiling panel, to assess the genomic fidelity of mouse tumor models. This tool aids in validating these models for translational cancer research by analyzing cross-species mutations and aneuploidy.

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Area of Science:

  • Genomics
  • Translational Cancer Research
  • Bioinformatics

Background:

  • The genomic fidelity of genetically engineered mouse models (GEMMs) to human cancers is largely uncharacterized.
  • Accurate preclinical models are crucial for advancing translational cancer research.

Purpose of the Study:

  • To develop and validate a comprehensive genomic profiling panel (MiMouse) for high-throughput credentialing of mouse tumor models.
  • To assess the genomic fidelity of GEMMs for high-grade serous carcinoma and colorectal carcinoma to their human counterparts.

Main Methods:

  • Developed MiMouse, a panel for comprehensive genomic profiling of formalin-fixed, paraffin-embedded mouse tumors.
  • Applied simulation and validation for cross-species mutation prioritization, strain determination, and aneuploidy detection.
  • Profiled >250 tumors from GEMMs of high-grade serous carcinoma and colorectal carcinoma.

Main Results:

  • Confirmed increased genomic instability in high-grade serous carcinoma GEMMs.
  • Identified Brca1 (B), Trp53 (P), Pten (Pt) mutated cancers as having the shortest latency and least genomic instability.
  • Highlighted the importance of synteny in colorectal cancer GEMMs, noting mouse chromosome 18 loss and mouse chromosome 5 gain with implications for tumor suppressor and oncogene loci.

Conclusions:

  • MiMouse provides a valuable tool for comprehensive genomic credentialing of mouse tumor models.
  • Understanding cross-species genomic differences is critical for the accurate application of GEMMs in cancer research.
  • Genomic profiling of GEMMs reveals insights into tumor evolution and the impact of synteny on genetic alterations.