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Updated: May 5, 2026

Time-lapse Imaging of Neuroblast Migration in Acute Slices of the Adult Mouse Forebrain
Published on: September 12, 2012
Auto-attraction of neural precursors and their neuronal progeny impairs neuronal migration
Julia Ladewig1, Philipp Koch1, Oliver Brüstle2
11] Institute of Reconstructive Neurobiology, LIFE and BRAIN Center, University of Bonn and Hertie Foundation, Bonn, Germany. [2].
Abstract:
Limited neuronal migration into host brain tissue is a key challenge in neural transplantation. We found that one important mechanism underlying this phenomenon is an intrinsic chemotactic interaction between the grafted neural precursor cells (NPCs) and their neuronal progeny. NPCs secrete the receptor tyrosine kinase ligands FGF2 and VEGF, which act as chemoattractants for neurons. Interference with these signaling pathways resulted in enhanced migration of human neurons from neural clusters.
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