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Related Concept Videos

Endocarditis I: Introduction01:25

Endocarditis I: Introduction

892
Introduction:Endocarditis is the infection of the endocardium, the inner lining of the heart and its valves. When the heart muscle is involved, the condition is termed myocarditis, while an infection of the outer lining is called pericarditis. Infective endocarditis (IE) primarily affects the endocardium, where pathogens adhere to the valves or lining, forming vegetation that can lead to severe complications. Infective endocarditis occurs when microorganisms, usually bacteria from other body...
892
Endocarditis II: Clinical Features of Infective Endocarditis01:25

Endocarditis II: Clinical Features of Infective Endocarditis

950
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
950
Endocarditis IV: Nursing Management01:29

Endocarditis IV: Nursing Management

637
Infective endocarditis (IE) is a chronic infection of the heart's endocardium, primarily affecting the heart valves. A detailed nursing assessment for a patient with IE involves collecting subjective and objective data to ensure an accurate diagnosis and timely intervention.Subjective DataThe nurse gathers information about the patient's symptoms and complaints during the subjective assessment. Patients with infective endocarditis often report non-specific symptoms that can mimic other...
637
Endocarditis III: Medical Management01:18

Endocarditis III: Medical Management

361
Infective endocarditis management involves a multifaceted approach encompassing infection prevention, lifestyle modifications, pharmacological therapy, and surgical management.Infection Prevention:Hand Hygiene: Thorough handwashing is crucial to prevent the spread of infection. Hand hygiene should be performed regularly, especially before and after using the restroom.Oral Hygiene: Good oral hygiene is essential. It includes brushing teeth immediately after waking up and before bed, flossing...
361
Myocarditis II: Clinical Features and Diagnostic Tests01:27

Myocarditis II: Clinical Features and Diagnostic Tests

496
Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
496
Myocarditis I: Introduction01:21

Myocarditis I: Introduction

647
Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
647

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Related Experiment Video

Updated: May 5, 2026

Isolation and Characterization of Cardiac Mesenchymal Stromal Cells from Endomyocardial Bioptic Samples of Arrhythmogenic Cardiomyopathy Patients
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Euthermic endocarditis.

Daniel C DeSimone1, Larry M Baddour, Brian D Lahr

  • 1Infectious Diseases, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America.

Plos One
|November 19, 2013
PubMed
Summary
This summary is machine-generated.

Lack of fever in infective endocarditis (IE) patients is linked to older age, longer symptom duration, and delayed diagnosis. However, fever absence does not significantly impact survival rates at 28 days or 1 year.

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Area of Science:

  • Cardiology
  • Infectious Diseases
  • Clinical Medicine

Background:

  • Infective endocarditis (IE) commonly presents with fever.
  • The clinical significance of fever absence in IE and its association with patient outcomes remain underexplored.
  • This study investigates the characteristics and outcomes of patients with euthermic IE.

Purpose of the Study:

  • To compare clinical characteristics and outcomes between patients with and without fever presenting with infective endocarditis.
  • To determine if the absence of fever in IE patients is an indicator of poorer prognosis.
  • To analyze factors such as age, symptom duration, diagnosis delay, and survival rates in euthermic versus febrile IE patients.

Main Methods:

  • Retrospective analysis of a single-center IE registry (Mayo Clinic, 1970-2006).
  • Inclusion of 240 euthermic IE cases meeting modified Duke criteria.
  • Comparison with 282 frequency-matched febrile IE controls.

Main Results:

  • Euthermic IE patients were older (median age 63.6 vs. 59.0 years) and had longer symptom duration before diagnosis (4.0 vs. 3.0 weeks).
  • Unadjusted 28-day and 1-year survival rates were similar between euthermic and febrile groups (87% vs. 83% and 72% vs. 69%, respectively).
  • A higher unadjusted 1-year incidence of valve surgery was observed in euthermic patients (50% vs. 39%).

Conclusions:

  • Absence of fever in IE patients is associated with older age, longer symptom duration, and delayed diagnosis.
  • Despite higher unadjusted valve surgery rates in euthermic patients, this difference was not significant after adjusting for confounders.
  • Lack of fever in IE does not appear to be a significant independent predictor of poorer survival at 28 days or 1 year.